Evidence map›Paper›PMID 42554874›Full record

ArticleArchives of microbiology2026

Differential apoptosis of GES-1 cells induced by Helicobacter pylori with heteroresistance to clarithromycin.

Xue Wang, Yingying Yang, Cui Wang, Lingzhu Gou, Muyang Li, Meirong Feng, Xiaofeng Zhou, Xusheng Ma, Dekui Zhang, Jianwei Yun

Abstract read
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In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xue WangThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Yingying YangThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Cui WangGansu Provincial People's Hospital, Lanzhou, 730030, China.
Lingzhu GouDepartment of Gastroenterology, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China.
Muyang LiDepartment of Gastroenterology, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China.
Meirong FengDepartment of Gastroenterology, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China.
Xiaofeng ZhouThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Xusheng MaDingxi Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Dingxi, China.
Dekui ZhangDepartment of Gastroenterology, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China.
Jianwei YunDepartment of Gastroenterology, The Second Hospital of Lanzhou University, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China. yjw2026ldey@163.com.

Funding

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital, CY2025-LC-B01Cuiying Scientific Training Program for Undergraduates of The Second Hospital & Clinical Medical School, Lanzhou University CYXZ2023-25Natural Science Foundation of Gansu Province, China 22JR11RA068The Gansu Province Key R&D Program 20YF8FA078
6 · The paper itself

Abstract

The heteroresistance of Helicobacter pylori to clarithromycin has been investigated intensively. This study aimed to examine the effects of H. pylori strains with heteroresistance to clarithromycin on the apoptosis of gastric epithelial (GES-1) cells. GES-1 cells were infected with clarithromycin-susceptible and -resistant (LSH53S/R) strains isolated from heteroresistant H. pylori LSH53 at a multiplicity of infection of 400:1. Subsequently, the cells were treated with clarithromycin, and apoptosis was assessed via flow cytometry. In addition, western blotting was used to evaluate the expression of apoptosis-related proteins and nuclear factor-kappa B (NF-κB) in GES-1 cells. GES-1 cells were incubated with LSH53S (S

Indexed as

Anti-Bacterial AgentsApoptosisClarithromycinDrug Resistance, BacterialEpithelial CellsHelicobacter InfectionsHelicobacter pyloribcl-2-Associated X ProteinCaspase 3Cell LineHumansNF-kappa BProto-Oncogene Proteins c-bcl-2Anti-Bacterial Agentsbcl-2-Associated X ProteinCaspase 3ClarithromycinNF-kappa BProto-Oncogene Proteins c-bcl-2ApoptosisGastric epithelial cells (GES-1)Helicobacter pyloriHeteroresistance to clarithromycinNF-κB/Bcl-2/Bax/caspase-3 pathway

Identifiers

PMID42554874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.