Evidence map›Paper›PMID 42554837›Full record

ArticleNeuroradiology2026

Investigation of cerebellar structure and static and dynamic functional connectivity in cervical spondylotic myelopathy patients.

Meng Liu, Siya Xu, Xianjun Zeng, Laichang He, Yongming Tan

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Meng Liu *Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Siya Xu *Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xianjun ZengJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Laichang HeJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yongming TanJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. ndyfy04394@ncu.edu.cn.

Funding

Clinical Research Center For Medical Imaging In Jiangxi Province 20223BCG74001Natural Science Foundation of Jiangxi Province 20192ACBL20039Science and Technology Research Project of Education Department of Jiangxi Province GJJ2200110the Key Laboratory of Precision Pathology and Intelligent Diagnosis of Jiangxi Province 2024SSY06281the Project of Jiangxi Provincial Health Commission No. 202610023
6 · The paper itself

Abstract

purposeTo investigate cerebellar structural and functional alterations in cervical spondylotic myelopathy (CSM) using multimodal MRI.

methods127 CSM patients and 91 healthy controls (HCs) underwent resting-state fMRI. Gray matter volume (GMV), static functional connectivity (sFC), and dynamic functional connectivity (dFC) were analyzed across 34 cerebellar subregions using the spatially unbiased infratentorial template (SUIT) atlas. Associations between altered imaging metrics and clinical measures were assessed.

results(1) CSM patients showed reduced GMV in left lobule V and vermal Crus I compared with HCs; however, these GMV reductions were not significantly associated with clinical measures (all P > 0.05). (2) Widespread cerebello-cerebral sFC alterations were observed in CSM patients, mainly involving interactions between the sensorimotor network (SMN) and default mode network (DMN), visual network (VN) interactions, dorsal attention network (DAN)-DMN/frontoparietal network (FPN) interactions, and deep nuclei-SMN/FPN interactions. The strength of specific sFC connections correlated with motor function and anxiety in CSM patients. (3) Cerebello-cerebral dFC analysis revealed network-dependent alterations in temporal variability, including increased variability in DAN-DMN/FPN, DMN/FPN-VN, and SMN-multiple association and VN pathways, and decreased variability in VN-DMN/FPN pathways. The temporal variability of specific dFC connections correlated with cognitive function.

conclusionCSM is associated with cerebellar atrophy and widespread alterations in cerebello-cerebral sFC and dFC. Some of these alterations were associated with clinical measures, providing evidence for cerebellar-cerebral network involvement in CSM, although their functional significance requires further clarification.

Indexed as

Cerebellar subregionsCervical spondylotic myelopathyDynamic functional connectivityFunctional magnetic resonance imagingGray matter volumeResting-state

Identifiers

PMID42554837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.