Evidence map›Paper›PMID 42554771›Full record

ArticleAnnals of biomedical engineering2026

Hemodynamic Effects of Aortic Stenosis on Coronary Flow Dynamics.

Roy Banay, Shiri Polak, Matan Danon, Oren Salimi, Ed David Hausmann, Ron Waksman, Yonathan Hasin, Idit Avrahami

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roy Banay *The Department of Mechanical Engineering & Mechatronics, Ariel University, P.O. Box 3, 40700, Ariel, Israel.
Shiri Polak *The Department of Mechanical Engineering & Mechatronics, Ariel University, P.O. Box 3, 40700, Ariel, Israel.
Matan DanonThe Adelson School of Medicine, Ariel University, 40700, Ariel, Israel.
Oren SalimiThe Department of Mechanical Engineering & Mechatronics, Ariel University, P.O. Box 3, 40700, Ariel, Israel.
Ed David HausmannThe Adelson School of Medicine, Ariel University, 40700, Ariel, Israel.
Ron WaksmanSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Yonathan HasinThe Adelson School of Medicine, Ariel University, 40700, Ariel, Israel.
Idit AvrahamiThe Department of Mechanical Engineering & Mechatronics, Ariel University, P.O. Box 3, 40700, Ariel, Israel. IditAv@Ariel.ac.il.ORCID http://orcid.org/0000-0003-4927-3491

Funding

Ministry of Science and Technology 1001829018
6 · The paper itself

Abstract

purposeAortic stenosis (AS) commonly coexists with coronary artery disease (CAD), yet the direct hemodynamic link between valve function, coronary flow waveforms, and spatial wall shear stress (WSS) remains poorly defined. This study isolates and quantifies how AS-induced flow alterations generate atheroprone coronary environments.

methodsAn in vitro mock circulation loop modeled severe AS (effective orifice area 0.7 cm

resultsCompared to TAVR, severe AS produced higher systolic transvalvular pressure gradients (45-70 mmHg vs. 10-25 mmHg) and lower aortic-sinus gradients, particularly at elevated heart rates (HR). Diastolic CBF was elevated at normal HR but declined with increasing HR, resulting in increased pulsatility and reduced coronary flow reserve. CFD revealed larger regions of atheroprone WSS in AS, predominantly on convex arterial curvatures, while elevated WSS localized to concave regions. TAVR reduced adverse WSS exposure by 30-50%.

conclusionAS induces hemodynamic disturbances associated with atheroprone environments through altered coronary flow and adverse WSS patterns. TAVR mitigates these effects, highlighting opportunities for valve design optimization to improve the local coronary fluid-dynamic environment.

Indexed as

Aortic stenosisComputational fluid dynamicsCoronary blood flowTranscatheter aortic valve replacementWall shear stress

Identifiers

PMID42554771

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.