ArticleArchives of microbiology2026
Identification and computational analysis of B-cell epitopes on the hemagglutinin protein of the H3N2 influenza virus.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Influenza A virus (IAV) is a highly infectious enveloped RNA virus that primarily causes respiratory disease. Continuous antigenic variation in influenza virus hemagglutinin (HA) is a major driver of influenza pandemics. Therefore, precise identification of B-cell epitopes within HA is essential for developing diagnostic tools and vaccine candidates that can help limit further influenza spread. In the present study, an integrated experimental and bioinformatics strategy was used. A trimeric HA protein was rationally designed to improve antigenicity and immunogenicity, expressed in a mammalian eukaryotic expression system, and purified by Ni-affinity chromatography. After animal immunization, nine HA-specific monoclonal antibodies (mAbs), namely 5D5, 6B8, 9E7, 13F8, 14C3, 15F6, 16B5, 17H7, and 20C5, were generated. These mAbs specifically recognized HA protein in western blotting and indirect immunofluorescence assays (IFA). B-cell epitopes on HA were subsequently mapped using these mAbs by indirect enzyme-linked immunosorbent assay (ELISA), dot-blot, western blotting, and IFA. Six previously unreported linear B-cell epitopes were identified:
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