Evidence map›Paper›PMID 42554501›Full record

ArticlemBio2026

BetaH proteolysis unleashes an electrostatic-homing antibacterial polymorphic toxin.

Daniel Mwangi, Maureen K Thomason, Lauren M Shull, Qing Tang, Joshua J Woodward

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Daniel MwangiDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0009-0000-3711-3314
Maureen K ThomasonDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0009-0005-5306-2103
Lauren M ShullDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-3644-0529
Qing TangDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3732-6675
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-4630-403X

Funding

Listeria monocytogenes physiology and host pathogen interactionsR01AI116669 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2015 to 2024
$4.4M
C-di-AMP signaling in S. aureusR01AI139071 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2019 to 2023
$2.8M
National Institute of Allergy and Infectious Diseases R01AI116669National Institute of Allergy and Infectious Diseases R01AI139071NIAID NIH HHS R01 AI116669NIAID NIH HHS R01 AI139071
6 · The paper itself

Abstract

Contact-dependent and diffusible proteinaceous polymorphic toxin systems (PTSs) mediate widespread bacterial competition. While bioinformatic analyses have identified diverse PTSs across bacterial phyla, experimental validation in gram-positive species remains limited. Here, we characterize a diffusible polymorphic toxin encoded by the IMPORTANCE: Polymorphic toxin systems (PTSs) are widely used by bacteria to inhibit competitors, but diffusible proteinaceous toxins have been largely characterized in gram-negative species. Here, we mechanistically characterize a diffusible PTS in

Indexed as

Anti-Bacterial AgentsBacterial ToxinsListeria monocytogenesStaphylococcus aureusAntibiosisATP-Binding Cassette TransportersBacterial ProteinsProteolysisStatic ElectricityAnti-Bacterial AgentsATP-Binding Cassette TransportersBacterial ProteinsBacterial Toxinsantagonismgram-positive bacteriatoxins

Identifiers

PMID42554501
PMCPMC13556192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.