ArticleApplied and environmental microbiology2026
A pathway for complete mineralization of the ambergris constituent (-)-Ambrox in
Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
(-)-Ambrox, the smelling principle in ambergris of sperm whales, is a saturated polycyclic terpenoid ether with multiple tertiary and quaternary centers. Despite these structural features, it is readily biodegradable and thus represents an interesting case to understand the degradation pathway of a complex, saturated polycyclic terpene. We isolated two IMPORTANCE: For complex, polycyclic natural substrates such as sesquiterpenes and diterpenes, there is little knowledge on biodegradation pathways, except for the elucidated steroid degradation pathways. This study presents key steps in the biodegradation pathway for (-)-Ambrox, a natural constituent of the sperm whale secretion ambergris, which was found to be readily biodegradable, despite a polycyclic ring system with multiple tertiary and quaternary carbon centers. This may be one of the first detailed studies on the biodegradation pathway of a polycyclic natural sesquiterpenoid.
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