Evidence map›Paper›PMID 42554464›Full record

ArticlemBio2026

The FleQ-FleN circuit balances flagellar number against fitness in

Anali Migueles-Lozano, Merrill Asp, Sofia T Rocha, Jiaqi Li, Georgia Fanouraki, Aden D Sun, Lichun Zhang, Jacob R Waldbauer, Jiarong Hong, Abhishek Shrivastava and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anali Migueles-LozanoDepartment of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA.
Merrill AspDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Sofia T RochaSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Jiaqi LiDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Georgia FanourakiDepartment of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA.
Aden D SunDepartment of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA.
Lichun ZhangDepartment of the Geophysical Sciences, University of Chicago, Chicago, Illinois, USA.
Jacob R WaldbauerDepartment of the Geophysical Sciences, University of Chicago, Chicago, Illinois, USA.
Jiarong HongDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-7860-2181
Abhishek ShrivastavaSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0003-1598-7509
Jing YanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Sampriti MukherjeeDepartment of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-5509-8776

Funding

Mechanistic investigation of bacterial type 9 secretion system machinery and its involvement in gut metabolism and immunomodulationR35GM147131 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Abhishek Shrivastava · 2022 to 2026
$2.0M
Probing the role of sensory cues in the regulation of bacterial biofilm developmentR35GM150803 · NIGMS · UNIVERSITY OF CHICAGO · PI Sampriti Mukherjee · 2023 to 2026
$1.8M
Charles H. Revson Foundation (25-19)National Science Foundation 2438891&2438892NIGMS NIH HHS R35 GM147131NIGMS NIH HHS R35GM147131NIGMS NIH HHS R35 GM150803NIGMS NIH HHS R35GM150803Simons Foundation SFI-LS-ECIAMEE-00006634
6 · The paper itself

Abstract

Evolutionary constraints governing flagellar number in bacterial pathogens remain poorly understood. While related

Indexed as

Bacterial ProteinsFlagellaGene Expression Regulation, BacterialGenetic FitnessPseudomonas aeruginosaTrans-ActivatorsAnimalsMutationVirulenceBacterial ProteinsFleQ protein, Pseudomonas aeruginosaTrans-Activatorsadaptive fitnessbiofilmsevolutionflagellar gene regulationPseudomonasvirulence

Identifiers

PMID42554464
PMCPMC13556257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.