Evidence map›Paper›PMID 42554462›Full record

ReviewEuropean thyroid journal2026

Management of thyroid emergencies: joint consensus statement on management of thyroid storm.

Peter Taylor, Onyebuchi Okosieme, Grigoris Effraimidis, Fraser Gibb, Dhruv Parekh, Carla Moran, Peter Kopp, Kristien Boelaert

Abstract readConsensus StatementReview
In one paragraph

Review in European thyroid journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter TaylorDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham , Birmingham, UK.ORCID 0000-0002-3436-422X
Onyebuchi OkosiemeThyroid Research Group, Systems Immunity Research Institute Cardiff University School of Medicine , Cardiff, United Kingdom.
Grigoris EffraimidisDepartment of Endocrinology and Metabolic Diseases, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa, Greece.ORCID 0000-0001-7313-8391
Fraser GibbEdinburgh Centre for Endocrinology & Diabetes, Royal Infirmary of Edinburgh , Edinburgh, UK.
Dhruv ParekhBirmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham , Birmingham, UK.
Carla MoranSchool of Medicine, University College Dublin , Dublin, Ireland.ORCID 0000-0002-7318-7166
Peter KoppDivision of Endocrinology, Diabetology and Metabolism, University of Lausanne , Lausanne, Switzerland.
Kristien BoelaertDepartment of Applied Health Research, School of Health Sciences, College of Medicine and Health, University of Birmingham , Birmingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid storm is a rare but life-threatening endocrine emergency characterised by extreme thyrotoxicosis and multi-organ dysfunction. Prompt recognition and rapid, coordinated management are essential to reduce its high mortality. This consensus statement, developed by experts in endocrinology and acute care, provides practical recommendations for the diagnosis and treatment of thyroid storm. Diagnosis remains clinical, aided by validated scoring systems such as the Burch-Wartofsky and Japanese Thyroid Association/Japan Endocrine Society criteria, which also predict outcomes. Management requires a multidisciplinary approach in high-dependency or intensive care settings, incorporating supportive measures, aggressive treatment of precipitating factors, and targeted therapies. Core treatments include beta-blockade, high-dose antithyroid drugs, corticosteroids, and iodide, with careful attention to timing and contraindications. Adjunctive therapies, such as cholestyramine, lithium, plasmapheresis, and extracorporeal membrane oxygenation (ECMO), as well as surgical thyroidectomy in selected cases, may be required for refractory disease. This guidance also highlights the need for definitive management of underlying hyperthyroidism after stabilisation. By summarising current evidence and expert consensus, this document aims to standardise care, support clinical decision-making, and improve outcomes in patients presenting with thyroid storm.

Indexed as

Thyroid CrisisAntithyroid AgentsEmergenciesHumansThyroidectomyAntithyroid AgentsBritish Thyroid AssociationBurch/WartofskyEuropean Thyroid AssociationguidelinesSociety for Endocrinologythyroid emergenciesthyroid stormthyrotoxicosis

Identifiers

PMID42554462
PMCPMC13506520

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.