ArticleMicrosurgery2026
Relationship Between Preoperative Coagulation Parameters and Risk of Flap Pedicle Thrombosis Following Free Flap Breast Reconstruction.
Article in Microsurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFlap pedicle thrombosis is a frequent cause of flap compromise, which is a major complication following free flap breast reconstruction. This study aims to investigate the relationship between preoperative coagulation parameters and the risk of postoperative flap pedicle thrombosis, providing guidance for preoperative assessment and perioperative management.
methodsA retrospective analysis was conducted on all patients who underwent free flap breast reconstruction at our institution between January 2021 and August 2025. Patient demographics, surgical details, preoperative coagulation test results (including prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin time, and D-dimer) and outcomes were recorded. Patients were categorized according to their preoperative coagulation test results. Demographics, surgical information, and incidence of flap pedicle thrombosis were compared between groups. Furthermore, patients were divided according to the occurrence of flap pedicle thrombosis. Preoperative coagulation parameters were compared between the two groups, and a multivariate logistic regression was performed to identify potential risk factors.
resultsA total of 154 patients (160 breasts) were included. Fifty-two breasts (32.5%) were categorized to the asymptomatic hypercoagulable group, and 108 breasts (67.5%) to the non-hypercoagulable group. Postoperative flap pedicle thrombosis occurred in nine breasts (5.6%), including two arterial thromboses and seven venous thromboses. No significant difference in postoperative flap pedicle thrombosis was observed between the two groups (9.6% vs. 3.7%, p = 0.152). Multivariate logistic regression indicated that immediate flap breast reconstruction might be an independent risk factor (p = 0.028).
conclusionThis study suggested no significant association between preoperative coagulation parameters (including PT, APTT, FIB, TT, and D-dimer) and flap pedicle thrombosis following free flap breast reconstruction.
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