Evidence map›Paper›PMID 42554416›Full record

ArticleTranslational vision science & technology2026

Repeatability of Foveal Sensitivity Measured Using Adaptive Optics Microperimetry.

Nivedhitha Govindasamy, William S Tuten, David H Brainard, Jessica I W Morgan

Abstract read
In one paragraph

Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Nivedhitha GovindasamyBioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
William S TutenHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, CA, USA.
David H BrainardDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
Jessica I W MorganScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Retinal structure, function and response to gene therapyR01EY028601 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Jessica I.W. Morgan · 2018 to 2026
$3.6M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY028601
6 · The paper itself

Abstract

Purpose: To assess the within and between-session repeatability of foveal sensitivity measurements using adaptive optics (AO) microperimetry. Methods: Five normal-sighted participants underwent AO microperimetry testing (550-nm circular stimulus) at the preferred retinal locus across two sessions (2 months ± 2 weeks). Two psychophysical paradigms were used: quick estimation of threshold (QUEST) and method of constant stimuli (MOCS). Each paradigm employed both 1.05-arcmin2 and 30.4-arcmin2 stimulus sizes; stimuli were not stabilized in real time. Trial-by-trial responses were fit with a logistic psychometric function to obtain thresholds at a criterion of 78% seen. Thresholds were converted to sensitivity. Statistical comparisons were performed using paired-sample t-tests. Results: Sensitivities measured from QUEST and MOCS procedures were not significantly different (QUEST: 1.05 arcmin2, P = 0.36 for session 1 and P = 0.41 for session 2; MOCS: 30.4 arcmin2, P = 0.14 for session 1 and P = 0.12 for session 2). Data were thus combined across paradigms for tests of repeatability. Sensitivities for data split into two groups within session 1 and separately within session 2 were not significantly different (QUEST: 1.05 arcmin2, P = 0.34 for session 1 and P = 0.51 for session 2; MOCS: 30.4 arcmin2, P = 0.31 for session 1 and P = 0.27 for session 2). Overall, sensitivities across the two sessions were not significantly different (QUEST: 1.05 arcmin2, P = 0.06; MOCS: 30.4 arcmin2, P = 0.81). The coefficients of repeatability across sessions were 1.5 decibels (dB) and 0.4 dB for 1.05 arcmin2 and 30.4 arcmin2, respectively. Conclusions: Sensitivity measurements from AO microperimetry were repeatable within and across sessions. Translational Relevance: Results of the present study will guide future longitudinal studies of disease progression in detecting sensitivity changes using AO microperimetry.

Indexed as

Fovea CentralisOptics and PhotonicsVisual FieldsVisual Field TestsAdultFemaleHumansMalePhotic StimulationPsychophysicsReproducibility of ResultsSensory ThresholdsYoung Adult

Identifiers

PMID42554416
PMCPMC13450651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.