ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionWe examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its association with encoding-related brain activity, controlling for emotional salience.
methodsParticipants (27 younger adults, 26 OAs, and 24 MCI) memorized emotional and neutral images during functional magnetic resonance imaging (MRI). Delayed memory was tested after 4 h and compared to immediate memory. LC contrast was measured via LC-sensitive MRI.
resultsMemory was lower, independent of delay or emotional valence, and LC contrast was more strongly reduced in those with MCI compared to OAs. In OAs, LC contrast correlated with delayed memory and was mildly associated with LC activity during successful encoding. All groups remembered emotional images better than neutral ones, though memory was greatly impaired in those with MCI. DISCUSSION: LC contrast was associated with lower brain activity during encoding and emotional salience processing. Its relationship to delayed memory was evident in those with MCI.
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