Evidence map›Paper›PMID 42554283›Full record

SynthesisJournal of paediatrics and child health2026

Hypermanganesemia in Children With Liver and Portosystemic Circulation Disorders: A Systematic Review.

Helena J Kim, Susan M Siew, Ji Hyun Moon, Tracey A Williams, S Murthy Chennapragada, Gordon Thomas, Shekeeb S Mohammad

Abstract readSystematic ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of paediatrics and child health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helena J KimFaculty of Medicine and Health, Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.ORCID https://orcid.org/0009-0006-8022-0880
Susan M SiewFaculty of Medicine and Health, Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0002-8987-119X
Ji Hyun MoonDepartment of Gastroenterology, Sydney Children's Hospitals Network, Westmead, Australia.ORCID https://orcid.org/0000-0002-5137-6134
Tracey A WilliamsKids Rehab, The Children's Hospital at Westmead, Westmead, Australia.
S Murthy ChennapragadaFaculty of Medicine and Health, Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0001-6177-8068
Gordon ThomasFaculty of Medicine and Health, Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0001-8416-0279
Shekeeb S MohammadFaculty of Medicine and Health, Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0003-1219-4781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimChildren with chronic liver disease and portosystemic circulation disorders may have long-term neurocognitive problems. Hypermanganesemia, reported in this group, could be a contributor. This systematic review aimed to characterise liver and portosystemic circulation disorders associated with hypermanganesemia and reported neurocognitive outcomes.

methodsMEDLINE, PubMed and Embase were systematically searched from inception to February 2023. Study quality and risk of bias were assessed using the Joanna Briggs Institute (JBI) critical appraisal tools and the Navigation Guide framework, respectively.

resultsEighteen studies (n = 103 patients) were included. Seventy of 103 had evidence of hypermanganesemia-47/78 with chronic liver disease and 23/25 with portosystemic shunts without liver disease. Among these, 40/70 had elevated manganese levels, 60/70 had characteristic MRI changes and 30/70 had both. Manganese levels and MRI abnormalities normalised in most cases following definitive treatment of chronic liver disease and portosystemic shunting. Neurocognitive outcomes were inconsistently reported.

conclusionsPortosystemic shunting is likely an important risk factor for hypermanganesemia in children with liver and portosystemic circulation disorders. Substantial gaps and biases limit firm conclusions about its independent contribution to neurocognitive outcomes, highlighting the need for a structured framework including shunt status, biochemical markers including manganese and longitudinal neurocognitive profiling.

Indexed as

Congenital Portosystemic ShuntLiver DiseasesManganeseChildHumansMagnetic Resonance ImagingManganese

Identifiers

PMID42554283
PMCPMC13671248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.