Evidence map›Paper›PMID 42554278›Full record

ArticleProtein science : a publication of the Protein Society2026

Conformational asymmetry of human immunodeficiency virus-1 protease flaps increases along the darunavir drug resistance pathway.

Michel Guerrero, Roman Zadorozhnyi, Guowu Lin, Caitlin M Quinn, Guillermo Calero, Nese Kurt-Yilmaz, Celia A Schiffer, Tatyana Polenova, Angela M Gronenborn, Rieko Ishima

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michel GuerreroDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Roman ZadorozhnyiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-2767-2002
Guowu LinDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-0823-0105
Caitlin M QuinnDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.ORCID 0000-0001-6172-7324
Guillermo CaleroDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-3730-4676
Nese Kurt-YilmazDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-5036-676X
Celia A SchifferDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-2270-6613
Tatyana PolenovaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.ORCID 0000-0002-0346-1131
Angela M GronenbornDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9072-3525
Rieko IshimaDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3418-0922

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGELA M. GRONENBORN · 2022 to 2026
$30.6M
Integration of Evolution to Avoid Resistance in Structure Based Drug DesignR01GM135919 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHIFFER, CELIA A. · 2020 to 2023
$2.5M
NIAID NIH HHS U54 AI170791NIGMS NIH HHS R01 GM135919NIH HHS AI170791NIH HHS GM135919University of Pittsburgh
6 · The paper itself

Abstract

Under selective drug pressure, the structure and dynamics of HIV-1 protease (PR) evolve to confer resistance to the drug. Here, we report on the conformational changes in PR flaps for drug-resistance mutations using

Indexed as

DarunavirDrug Resistance, ViralHIV-1HIV ProteaseHIV Protease InhibitorsHumansModels, MolecularMutationNuclear Magnetic Resonance, BiomolecularProtein ConformationDarunavirHIV ProteaseHIV Protease Inhibitorsp16 protease, Human immunodeficiency virus 1dynamicsfluorine‐19 NMRHIV‐1 proteaseNMRprotein dynamicsrelaxationstructure

Identifiers

PMID42554278
PMCPMC13439748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.