ArticleThe Journal of antimicrobial chemotherapy2026
Genome-wide network of antibiotic susceptibility in Pseudomonas aeruginosa.
Article in The Journal of antimicrobial chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivePseudomonas aeruginosa is a ubiquitous Gram-negative pathogen notorious for causing infections with high mortality rates. Its large genome supports extensive metabolic diversity and promotes its adaptation to diverse environments. The survival and persistence of P. aeruginosa in clinical settings is further facilitated by a vast arsenal of strategies that contribute to its tolerance or resistance to antibiotics. Here, we aimed to systematically identify the genetic determinants that affect its susceptibility to antibiotics.
methodsThe ordered PA14 transposon mutant library was grown in the presence of sub-MIC concentrations of a panel of antibiotics of various classes, and the growth of each mutant was quantified to generate susceptibility scores.
resultsWe observed a dense network of genes affecting antibiotic susceptibility in P. aeruginosa, where a large portion of genes modulated susceptibility to various classes of antibiotics. Not surprisingly, efflux and outer membrane permeability were key contributors, but we also identified genes that are not typically associated with antibiotic susceptibility.
conclusionsThe data provide a genome-wide view of the antibiotic susceptibility network in P. aeruginosa. Overall, our approach deepens our understanding of antibiotic susceptibility and opens new avenues for developing strategies against multidrug-resistant P. aeruginosa.
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