ArticleKidney diseases (Basel, Switzerland)
Peripheral Blood Lymphocyte Subsets and Clinical Parameters in Patients Undergoing Renal Biopsy.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Chronic kidney disease (CKD) is a major global health burden characterized by immune dysregulation. Peripheral blood lymphocyte subsets can reflect immune status across CKD pathologies. We evaluated associations between lymphocyte subsets and clinical parameters in patients undergoing renal biopsy in a contemporary cohort. Methods: We conducted a retrospective cross-sectional study of adults (≥16 years) who underwent native renal biopsy at Tongji Hospital, China, from January 2012 to December 2024. The lymphocyte subsets assessed by flow cytometry included combined T/B/NK cells (TBNK), total T cells (CD3 Results: In total, 1,033 individuals were enrolled. TBNK levels declined with age (β = -4.33, 95% CI: -7.35 to -1.32) and were lower in females than males (β = -84.26, 95% CI: -157.29 to -11.23). Lymphocyte subset distributions varied by nephritis pathology: ANCA-GN and lupus nephritis showed lower levels than other types, whereas purpura nephritis was relatively higher. TBNK counts correlated positively with estimated glomerular filtration rate (β = 11.48, 95% CI: 6.78 to 16.19), with similar patterns for total B, total T, CD4 Conclusions: Lymphocyte and subset counts relate to renal function, immune indices, and pathology. Their measurement may help evaluate disease severity and immune status in nephritis and inform clinical management.
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