Evidence map›Paper›PMID 42553890›Full record

ArticleOrganic process research & development2026

A Practical and Scalable-Oriented Enantioselective Synthesis of (

Alessandro Brusa, Matteo Bottiglieri, Carola Tomassi, Francesco Feola, Daniele Lanaro, Andrea Bonetti, Gabriella Zappia, Federico Sala, Andrea Gambini, Mario Falzoni and 6 more

Abstract read
In one paragraph

Article in Organic process research & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Practical and Scalable-Oriented Enantioselective Synthesis of (Organic process research & development · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandro BrusaDepartment of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila 67100, Italy.
Matteo BottiglieriDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Venezian 21, Milan I-20133, Italy.
Carola TomassiDepartment of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila 67100, Italy.
Francesco FeolaIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Daniele LanaroIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Andrea BonettiIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Gabriella ZappiaIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Federico SalaIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Andrea GambiniIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Mario FalzoniIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Pietro AllegriniIndena s.p.a., Via Don Minzoni 6, Settala, MI 20049, Italy.
Maria Luisa GelmiDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Venezian 21, Milan I-20133, Italy.ORCID https://orcid.org/0000-0003-0743-5499
Massimiliano AschiDepartment of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila 67100, Italy.ORCID https://orcid.org/0000-0003-2959-0158
Andrea MazzantiDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Via P. Gobetti 85, Bologna I-40129, Italy.ORCID https://orcid.org/0000-0003-1819-8863
Fabio PesciaioliDepartment of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila 67100, Italy.
Armando CarloneDepartment of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila 67100, Italy.ORCID https://orcid.org/0000-0003-2983-6445

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A process-friendly and enantioselective total synthesis of (

Indexed as

asymmetric synthesisBischler−Napieralski cyclizationcircular dichroismisoquinoline alkaloids

Identifiers

PMID42553890
PMCPMC13436619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.