Evidence map›Paper›PMID 42553888›Full record

ArticleOcular oncology and pathology2026

Identification and Validation of an E2F Targets-Related Gene Signature Risk Score Predicting the Prognosis of Patients with Uveal Melanoma.

Ahmed H Al Sharie, Mais B Tashtoush, Reem F Darweesh, Rand K Jadallah, Jawad M Al-Karaki, Samah O Al-Omari, Abdelwahab J Aleshawi, Asem A Alqudah, Amer Alemam, Hashem Abu Serhan and 3 more

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Article in Ocular oncology and pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Ahmed H Al SharieDepartment of Internal Medicine, Southeast Health, Dothan, AL, USA.
Mais B TashtoushDivision of Ophthalmology, Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Reem F DarweeshDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Rand K JadallahDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Jawad M Al-KarakiDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Samah O Al-OmariDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Abdelwahab J AleshawiDivision of Ophthalmology, Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Asem A AlqudahDivision of Ophthalmology, Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Amer AlemamEye Specialty Hospital, Amman, Jordan.
Hashem Abu SerhanDepartment of Ophthalmology, Hamad Medical Corporations, Doha, Qatar.
Ayman G ElnahryDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Tamam El-ElimatDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Rami Al-DwairiDivision of Ophthalmology, Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Uveal melanoma (UM) is a challenging malignancy, in terms of diagnosis, risk stratification, and treatment associated with high morbidity and mortality rates. It has been demonstrated that E2F-related pathways play a significant role in the tumorigenesis and distant metastasis of UM. In this study, the E2F target-related genes were utilized to construct and validate a prognostic risk score for patients with UM. Methods: Using the TCGA-UVM cohort ( Results: A total of 9 genes ( Conclusion: The developed E2F target-related gene model offers a robust tool for predicting the prognosis of UM patients. As a potential risk stratification method for UM, this model could have clinical applications pending further evaluation.

Indexed as

E2F target-related genesimmune microenvironmentPrognostic risk scoreThe Cancer Genome Atlas Program databaseUveal melanoma

Identifiers

PMID42553888
PMCPMC13436978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.