ArticleSaudi journal of anaesthesia
Regional anesthesia in breast surgery: An Italian expert consensus - Part 2: Results from a network meta-analysis evaluating 103 randomized controlled trials on regional anesthesia techniques for mastectomy with or without axillary clearance.
Article in Saudi journal of anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional anesthesia techniques are increasingly used to improve analgesia and reduce opioid consumption after breast surgery. Several approaches have been proposed, including paravertebral block and different fascial plane blocks, but their comparative effectiveness remains uncertain. This network meta-analysis (NMA) aimed to compare the efficacy and safety of regional anesthesia techniques in patients undergoing mastectomy with or without axillary clearance. A systematic review and NMA of randomized controlled trials were conducted according to established methodological guidelines. Studies evaluating regional anesthesia techniques in patients undergoing mastectomy were included. Outcomes assessed were intraoperative opioid consumption, 24-hour postoperative morphine milligram equivalents (MMEs), pain at rest and with movement at 12 and 24 hours, postoperative nausea and vomiting (PONV), use of rescue analgesics, and the incidence of complications such as pneumothorax and local anesthetic systemic toxicity (LAST). Regional anesthesia techniques were associated with improved analgesic outcomes compared with LA infiltration or no regional block. Paravertebral block showed the most consistent benefit across outcomes, particularly for opioid consumption and postoperative pain. Fascial plane blocks demonstrated comparable performance to paravertebral blocks for most outcomes, although paravertebral blocks showed superior results for pain on movement. LA infiltration alone or the absence of regional anesthesia performed worse across most outcomes. Serious complications were rarely reported. Paravertebral block appears to provide the most consistent analgesic benefit for mastectomy when performed by experienced practitioners. Fascial plane blocks represent a reasonable alternative when a paravertebral block is not feasible. Simple surgical infiltration alone appears insufficient for optimal analgesia in major breast surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.