Evidence map›Paper›PMID 42553777›Full record

ArticleBrain communications2026

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.

Enrico Premi, Damiano Archetti, Alberto Redolfi, Valeria Bracca, Valentina Cantoni, Armin Iraji, Vince D Calhoun, Sonia Bellini, Roberta Ghidoni, Roberto Gasparotti and 35 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Enrico PremiStroke Unit, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili, Brescia 25123, Italy.ORCID https://orcid.org/0000-0002-4342-6963
Damiano ArchettiLaboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia 25125, Italy.
Alberto RedolfiLaboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia 25125, Italy.
Valeria BraccaDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy.
Valentina CantoniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy.
Armin IrajiTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech and Emory, Atlanta, GA 30303, USA.
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech and Emory, Atlanta, GA 30303, USA.
Sonia BelliniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia 25125, Italy.ORCID https://orcid.org/0000-0002-6162-252X
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia 25125, Italy.
Roberto GasparottiNeuroradiology Unit, University of Brescia, Brescia 25123, Italy.
Arabella BouziguesINSERM U1127, Paris Brain Institute, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris 75013, France.ORCID https://orcid.org/0000-0002-0267-8590
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
Phoebe H FosterDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
Eve Ferry-BolderDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam 3000 CA, Netherlands.
Lize C JiskootDepartment of Neurology, Erasmus Medical Centre, Rotterdam 3000 CA, Netherlands.ORCID https://orcid.org/0000-0002-1120-1858
Harro SeelaarDepartment of Neurology, Erasmus Medical Centre, Rotterdam 3000 CA, Netherlands.ORCID https://orcid.org/0000-0003-1989-7527
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut D'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona 08036, Spain.
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, Québec City, Canada G1J 1Z4.
Caroline GraffDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet, Solna 171 64, Sweden.ORCID https://orcid.org/0000-0002-9949-2951
Daniela GalimbertiFondazione IRCCS Ca' Granda, Dipartimento Area Neuroscienze e Salute Mentale, Ospedale Maggiore Policlinico, Milan 20122, Italy.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.ORCID https://orcid.org/0000-0001-6237-2502
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon 1649-028, Portugal.
Giuseppe Di FedeDipartimento di Neuroscienze Cliniche, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20126, Italy.
Isabel SantanaNeurology Service, Faculty of Medicine, University Hospital of Coimbra, University of Coimbra, Coimbra 3004-561, Portugal.
Alexander GerhardDivision of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Manchester M20 3JJ, UK.ORCID https://orcid.org/0000-0002-8071-6062
Johannes LevinDepartment of Neurology, Ludwig-Maximilians Universität München, Munich 80336, Germany.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50139, Italy.
Markus OttoDepartment of Neurology, University of Ulm, Ulm 89081, Germany.
Maxime BertouxInserm, Lille Neuroscience & Cognition U1172, University of Lille, CHU Lille, Lille 5900, France.ORCID https://orcid.org/0000-0002-5283-503X
Thibaud LebouvierInserm, Lille Neuroscience & Cognition U1172, University of Lille, CHU Lille, Lille 5900, France.
Simon DucharmeDouglas Mental Health University Institute, Department of Psychiatry, McGill University Health Centre, McGill University, Montreal, Québec, Canada H4A 3J1.ORCID https://orcid.org/0000-0002-7309-1113
Christopher R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford OX3 9DU, UK.ORCID https://orcid.org/0000-0002-7502-9284
Isabelle Le BerINSERM U1127, Paris Brain Institute, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris 75013, France.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada N6A 5A5.ORCID https://orcid.org/0000-0003-4461-7427
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5T 0S8.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada M4N 3M5.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 0QQ, UK.
Matthis SynofzikDivision Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen 72076, Germany.ORCID https://orcid.org/0000-0002-2280-7273
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian 20014, Spain.
Henrik ZetterbergDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3AR, UK.
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy.
GENetic Frontotemporal dementia Initiative (GENFI)
GENetic Frontotemporal dementia Initiative (GENFI)

Funding

Wellcome Trust
6 · The paper itself

Abstract

Individuals with autosomal dominant frontotemporal dementia (FTD) exhibit considerable variability in disease onset and progression. Both modifiable and non-modifiable factors-such as sex, educational attainment or geographic region of residence-may contribute to this heterogeneity, potentially through their influence on cognitive reserve. The aim of the present study was to investigate the role of cognitive reserve modulators within the Genetic Frontotemporal dementia Initiative (GENFI) cohort. To this end, we used functional MRI (i.e. spatial chronnectome measures) and neurodegenerative markers (i.e. plasma neurofilament light chains levels) to determine disease stage using a Discriminative Event-Based Model (DEBM). We then examined how potential modulators influence the relationship between disease stage and cognitive performance. We analysed a total of 711 participants, including 106 patients with genetic FTD, 325 presymptomatic mutation carriers and 280 non-carriers healthy controls. Female participants showed a weaker association between disease stage and cognitive performance compared to males (

Indexed as

Discriminative Event-Based Model (DEBM)educationfrontotemporal lobar degenerationgeneticsex

Identifiers

PMID42553777
PMCPMC13435617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.