Evidence map›Paper›PMID 42553752›Full record

ArticleBrain communications2026

Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder.

Christiana Westlin, Cristina Bleier, Andrew J Guthrie, Sara A Finkelstein, Julie Maggio, Jessica Ranford, Julie MacLean, Ellen Godena, Daniel Millstein, Jennifer Freeburn and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Christiana WestlinMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-9127-0847
Cristina BleierMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Andrew J GuthrieMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sara A FinkelsteinMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Julie MaggioDepartment of Physical Therapy, Massachusetts General Hospital, Boston, MA 02114, USA.
Jessica RanfordDepartment of Occupational Therapy, Massachusetts General Hospital, Boston, MA 02114, USA.
Julie MacLeanDepartment of Occupational Therapy, Massachusetts General Hospital, Boston, MA 02114, USA.
Ellen GodenaMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Daniel MillsteinMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jennifer FreeburnDepartment of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Caitlin AdamsMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Christopher D StephenMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-4727-192X
Ibai DiezComputational Neuroimaging Lab, Biobizkaia Health Research Institute, Barakaldo 48903, Spain.
David L PerezMass General Brigham Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-2721-583X

Funding

Defining Neurobiological Subtypes of Motor Functional Neurological DisorderR01MH125802 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PEREZ, DAVID LEWIS · 2021 to 2025
$3.9M
NIMH NIH HHS R01 MH125802
6 · The paper itself

Abstract

Clinical trajectories in patients with functional neurological disorder (FND) are variable, and the neural mechanisms underlying this heterogeneity remain poorly understood. This longitudinal brain imaging study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND. Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and functional MRI (fMRI), followed by naturalistic treatment for 6.8 ± 0.8 months. All participants completed follow-up questionnaires; 28 completed follow-up fMRI. At each timepoint, three graph-theory network metrics of resting-state functional connectivity were computed: whole-brain weighted-degree (centrality), cortical integration (

Indexed as

fMRIfunctional movement disorderfunctional seizuresgraph theoryoutcomes

Identifiers

PMID42553752
PMCPMC13435623

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.