ArticleRSC advances2026
Temperature-controlled conformational switching of squaramides enabled by side-chain hydrogen bonding.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Precise control of local conformational bias is essential for constructing stimulus-responsive aromatic architectures. Amide-derived scaffolds such as squaramides are particularly attractive targets, as their moderate rotational barriers allow thermodynamic tuning without irreversible locking. Here we demonstrate that introduction of a hydrogen-bond-accepting side chain enables thermodynamic programming of squaramide conformations. The triethylene glycol (TEG) substituent of squaramide 1c bearing a pyrene moiety induces reversible temperature-dependent switching between (
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