Evidence map›Paper›PMID 42553659›Full record

ArticleFrontiers in medicine2026

A pilot study of nebulized 3D-cultured mesenchymal stem cell-derived extracellular vesicles for the treatment of post-COVID-19 chronic cough.

Jihui Du, Yunong Wang, Hongyan Wang, Hongjie Zou, Chu Hua, Weihan Xie, Jiming Chen, Zhijiang Yu, Xilin Shen, Keke Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jihui Du *Research Center for Clinical and Translational Medicine, Shenzhen Nanshan People's Hospital and Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Yunong Wang *Translational Research Center of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong, China.
Hongyan WangDepartment of Infectious Diseases and Shenzhen Key Laboratory for Endogenous Infection, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Hongjie ZouResearch Center for Clinical and Translational Medicine, Shenzhen Nanshan People's Hospital and Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Chu HuaTranslational Research Center of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong, China.
Weihan XieREGEN-αGEEK Medical Technology Co., Ltd, Shenzhen, China.
Jiming ChenDepartment of Respiratory and Critical Care Medicine, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Zhijiang YuDepartment of Infectious Diseases and Shenzhen Key Laboratory for Endogenous Infection, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Xilin ShenDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Keke WuSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
Cheng ZhangREGEN-αGEEK Medical Technology Co., Ltd, Shenzhen, China.
Wenhao WangTranslational Research Center of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong, China.
Bingbing WuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Zhiyong ZhangTranslational Research Center of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic cough, particularly prevalent in post-COVID condition (PCC, also known as long COVID), remains a significant medical challenge. Recently, extracellular vesicles (EVs) have gained significant attention for their therapeutic potential. Methods: In this study, we explore the therapeutic effects of EVs derived from mesenchymal stem cells (MSCs) cultured in a 3D system (3D-EVs) in treating chronic cough, with a focus on post-COVID-19 patients. Results: Our Conclusion: These findings demonstrate the feasibility and preliminary efficacy of 3D-EVs for rapid relief of post-COVID-19 chronic cough, supporting larger controlled trials to validate their role in this and related respiratory diseases.

Indexed as

3D cultureextracellular vesiclesimmunomodulationmesenchymal stem cellsnebulization therapypost-COVID-19 chronic cough

Identifiers

PMID42553659
PMCPMC13435666

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