Evidence map›Paper›PMID 42553497›Full record

ReviewResearch (Washington, D.C.)2026

Microneedle-Assisted Cell Delivery and Therapy.

Ruochen Qiao, Dasheng Li, Long Wang, Chenxuan Zhao, Bin Kong, Jinhui Wu

Abstract readReview
In one paragraph

Review in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruochen QiaoState Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing University, Nanjing 210093, China.
Dasheng LiDepartment of Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210031, China.
Long WangState Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing University, Nanjing 210093, China.
Chenxuan ZhaoState Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing University, Nanjing 210093, China.
Bin KongSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
Jinhui WuState Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing University, Nanjing 210093, China.ORCID https://orcid.org/0000-0001-8809-1290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-based therapeutics hold immense promise for clinical intervention, yet their practical translation is severely bottlenecked by suboptimal delivery kinetics, safety risks, and low patient adherence. This review provides a comprehensive overview of recent innovations in microneedle (MN)-based cell delivery systems and their applications across multiple organs. We initiate the discussion by evaluating progress in regenerative medicine, specifically targeting stem and immune-derived lineages. The article further classifies MN systems for cell therapy delivery according to material composition, fabrication techniques, and functional characteristics, with an in-depth discussion of innovative designs, highlighting their unique advantages. Additionally, we categorize and analyze recent studies on MN-based cell therapy for skin diseases, endometrial repair, cardiac regeneration, and oral disorders. Beyond summarizing current achievements, we critically examine the translational barriers that limit clinical adoption, including manufacturing scalability, storage stability, and regulatory considerations. This review provides a systematic and organ-specific overview that may help guide the design of improved and more clinically translatable cell delivery platforms.

Identifiers

PMID42553497
PMCPMC13433927

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.