ArticleRSC advances2026
Plug-and-play coaxial nested-tube supported liquid membrane extraction for the determination of nonsteroidal anti-inflammatory drugs in human plasma.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
A robust coaxial nested-tube supported liquid membrane extraction (CNT-SLME) method was developed for determining nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma. The device was adapted from commercial nucleic acid purification columns using industrial-grade polypropylene fabric as a stable, hydrophobic support for a dihexyl ether liquid membrane. This "plug-and-play" three-phase system (acidic donor/organic membrane/alkaline acceptor) facilitates efficient analyte enrichment and reduced matrix interference. The setup allows simultaneous processing of multiple samples using a standard multi-well shaker, overcoming the low-throughput bottlenecks of traditional liquid-phase microextraction. Under optimized conditions, the method yielded satisfactory recoveries (46.89-66.63%), negligible matrix effects (86.50-103.51%), excellent linearity (
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