Evidence map›Paper›PMID 42553411›Full record

Observational studyJournal of nutritional science2026

Protein intake, physical activity, and skeletal muscle outcomes in middle-aged adults: an observational study from the US.

Konstantinos Prokopidis, Brendon Stubbs, Nicola Veronese, Stefano Cacciatore, Paolo Piaggi, Carla M Prado, John A Batsis, Mathias Schlögl

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of nutritional science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantinos ProkopidisDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, UK.ORCID https://orcid.org/0000-0002-6264-9388
Brendon StubbsDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Italy.
Stefano CacciatoreDepartment of Physiology and Aging, University of Florida, Italy.
Paolo PiaggiPhoenix Epidemiology & Clinical Research Branch, NIDDK Phoenix Epidemiology and Clinical Research Branch, USA.ORCID https://orcid.org/0000-0003-2774-9161
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Canada.
John A BatsisDivision of Geriatric Medicine, The University of North Carolina at Chapel Hill, USA.
Mathias SchlöglDepartment for Geriatric Medicine, Klinic Barmelweid, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia, the age-related decline in muscle mass and strength is a growing challenge for older adults. This study investigates whether meeting the WHO physical activity guidelines (150-300 min/week of moderate or 75 min/week of vigorous exercise) with higher protein intake, based on the RDA, is associated with appendicular lean soft tissue index (ALSTI) and handgrip strength (HGS) in adults living in the United States aged 40-59 years. Data from the National Health and Nutrition Examination Survey 2007-2020 included 2540 adults aged ≥40 years. Physical activity (moderate/vigorous) was self-reported, while higher protein intake was assessed via two 24-hour recalls (>0.8 g/kg/bodyweight). Linear regressions, adjusted for age, sex, BMI, race, education, comorbidities, and energy-adjusted protein intake were used to assess associations with ALSTI and HGS. In fully adjusted models, vigorous activity with higher protein intake (47.1 ± 5.6 years) was associated with ALSTI only after adjustments for age, sex, BMI, race, education (

Indexed as

Dietary ProteinsExerciseMuscle, SkeletalAdultBody Mass IndexFemaleHand StrengthHumansMaleMiddle AgedNutrition SurveysSarcopeniaUnited StatesDietary Proteinsbody compositionmuscle healthNutritionphysical activityprotein intakesarcopenia

Identifiers

PMID42553411
PMCPMC13434054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.