ArticleNeurotrauma reports
Peripheral and Central Administration of Soluble Glycoprotein 130 Improves Cognitive Outcomes Following Controlled Cortical Impact in Male Mice.
Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
Traumatic brain injury (TBI) initiates complex immune responses, including upregulation of interleukin (IL)-6, a cytokine associated with clinical outcomes after injury. IL-6 trans-signaling, via the solubilized IL-6 receptor, drives pro-inflammatory cascades and is selectively inhibited by soluble glycoprotein 130 (sgp130). Although chronic intermittent sgp130Fc fusion protein (sgp130Fc) treatment after TBI has shown benefits across species, optimal dosing remains unclear. This study evaluated the effects of a single sgp130Fc dose (2 μg intrahippocampally or 10 μg intraperitoneally) in male mice on day three following controlled cortical impact or sham procedures. Cognitive performance was assessed using the Morris water maze, and histological assessment included lesion volume and microglia quantification. Intrahippocampal sgp130Fc improved spatial memory during probe trials, decreasing latency to the platform zone (
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