Evidence map›Paper›PMID 42553273›Full record

ArticleFrontiers in microbiology2026

Precise mapping of two conserved minimal epitopes on the nucleocapsid protein of porcine epidemic diarrhea virus.

Youhao Bu, Ruiqin Zhu, Ao Jiang, Yanze Li, Liuyang Jiao, Xun Huang, Lu Xia, Hui Hu, Gaiping Zhang, Yanan Wu

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Youhao Bu *International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Ruiqin Zhu *International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Ao JiangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Yanze LiInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Liuyang JiaoInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Xun HuangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Lu XiaInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Hui HuInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Gaiping ZhangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Yanan WuInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric pathogen that causes severe diarrhea and high mortality in neonatal piglets, leading to substantial economic losses in the swine industry. The nucleocapsid (N) protein is highly conserved and abundantly expressed during infection, making it a suitable target for serological detection. Methods: In this study, twomonoclonal antibodies (mAbs), C9 and G11, directed against the PEDV N protein were used to define minimal linear epitopes. A stepwise truncation approach based on overlapping recombinant fragments was applied to localize the antigenic regions. Results: The results showed that mAb C9 and mAb G11 recognized the minimal epitopes Discussion: These findings provide a more precise characterization of antigenic sites within the PEDVNprotein andmay be useful for the development of specific and reliable serological assays.

Indexed as

epitope mappingmonoclonal antibodynucleocapsid proteinporcine epidemic diarrhea virus (PEDV)truncation strategy

Identifiers

PMID42553273
PMCPMC13433615

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