Evidence map›Paper›PMID 42553126›Full record

ArticleFrontiers in endocrinology2026

Case Report: a family presenting with β-adrenergic/vasopressin-responsive bilateral macronodular adrenal disease with an

Masanori Arai, Masato Ono, Ryota Inoue, Kazuki Tajima, Kota Aomori, Tomoyuki Tatenuma, Sawako Suzuki, Shoji Yamanaka, Satoshi Fujii, Yasuo Terauchi and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masanori AraiDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Masato OnoDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Ryota InoueDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Kazuki TajimaDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Kota AomoriDepartment of Urology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Tomoyuki TatenumaDepartment of Urology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Sawako SuzukiDepartment of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shoji YamanakaDepartment of Pathology, Yokohama City University Hospital, Yokohama, Japan.
Satoshi FujiiDepartment of Pathology, Yokohama City University Hospital, Yokohama, Japan.
Yasuo TerauchiDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Jun ShirakawaDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bilateral macronodular adrenal disease (BMAD), also referred to as primary bilateral macronodular adrenal hyperplasia (PBMAH), represents a rare etiology of subclinical or overt Cushing's syndrome (CS), characterized by the presence of multiple large nodules in both adrenal glands. Although historically considered a sporadic condition, familial cases of BMAD have become increasingly recognized in recent years. As early surgical intervention is typically chosen for these familial cases, evidence on the long-term effectiveness of conservative medical therapy remains scarce. Here, we report a Japanese parent-child pair with subclinical and overt CS with genetically confirmed BMAD in which both individuals harbored

Indexed as

Armadillo Domain ProteinsCushing SyndromeMetyraponeMutationAdultChildHumansPedigreeArmadillo Domain ProteinsARMC5 protein, humanMetyraponeARMC5bilateral macronodular adrenal diseaseBMADCushing’ s syndromeJapanesemetyrapone

Identifiers

PMID42553126
PMCPMC13433298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.