Rectal Ulceration as an Atypical Initial Gastrointestinal Manifestation of Advanced HIV Infection: A Case Report.

Timmer Verhaegh, Anais Panossian, Anna N Skay, Zubair Ilyas, Aram A Namavar

Abstract readCase Reports

In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timmer VerhaeghInternal Medicine, University of California, Los Angeles (UCLA), Los Angeles, USA.

Anais PanossianInternal Medicine, University of California, Los Angeles (ULCA), Los Angeles, USA.

Anna N SkayGastroenterology, University of California, Los Angeles (ULCA) Health, Los Angeles, USA.

Zubair IlyasMedicine, University of California, Los Angeles (ULCA) Health, Los Angeles, USA.

Aram A NamavarMedicine, University of California, Los Angeles (ULCA) Health, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) infection can involve the gastrointestinal tract, most commonly resulting in esophageal ulceration. Rectal ulceration associated with HIV is rare and sparsely reported. We describe a 34-year-old male who presented with melena and rectal pain and was found to have large, deep rectal ulcers on colonoscopy. Expanded infectious testing revealed a new diagnosis of advanced HIV infection with an HIV RNA viral load greater than one million copies/mL (log 6.16) and a positive hepatitis C antibody. Additional evaluation demonstrated negative test results for syphilis, gonorrhea, and chlamydia, while the rectal biopsy was negative for cytomegalovirus (CMV), herpes simplex virus (HSV), fungal organisms, granulomatous disease, and malignancy. This case highlights the importance of considering HIV infection in the differential diagnosis of atypical rectal ulceration and illustrates a rare presentation of HIV-associated gastrointestinal disease.

Indexed as

advanced hivgastrointestinal manifestationshivrectal ulcerviral load

Identifiers

PMID42553072

DOI10.7759/cureus.112052

PMCPMC13433131

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.