Evidence map›Paper›PMID 42552960›Full record

ArticleJournal of neuroendocrinology2026

Enduring autism-like phenotypes and deregulated hypothalamic prosocial peptides after early-life exposure to indoor flame retardants in male C57BL/6 mice.

Elena V Kozlova, Gwendolyn M Gonzalez, Maximillian E Denys, Anthony E Bishay, Roberto Gutierrez, Jack Reid, Julia M Krum, Gregory Lampel, Naran Luvsanravdan, Kayhon M Rabbani and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Elena V KozlovaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0000-0002-4691-6618
Gwendolyn M GonzalezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Maximillian E DenysDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0000-0002-7423-6265
Anthony E BishayDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0000-0002-6057-3770
Roberto GutierrezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Jack ReidDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Julia M KrumDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Gregory LampelDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Naran LuvsanravdanDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0009-0001-9881-5747
Kayhon M RabbaniDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Jordan TuDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Luis CampoyDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Laura M AnchondoDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0009-0007-8942-9768
Crystal N LunaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0009-0003-3003-0665
Duraan S OlomiDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Eduardo MonarrezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Valeria CarrilloDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Jasmin D TranDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Damon PlattDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Yash KordeDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Bhuvaneswari D ChinthirlaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Maher BlaibelDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Simon KimDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.
Gladys ChompreDepartment of Biotechnology, Pontifical Catholic University of Puerto Rico, Ponce, Puerto Rico, USA.
Allison L PhillipsNicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Heather M StapletonNicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Bernhard HenkelmannHelmholtz Zentrum München, German National Research Centre for Environmental Health (GmbH), Molecular EXposomics (MEX), Neuherberg, Germany.
Karl-Werner SchrammHelmholtz Zentrum München, German National Research Centre for Environmental Health (GmbH), Molecular EXposomics (MEX), Neuherberg, Germany.ORCID https://orcid.org/0000-0002-8945-4062
Margarita C Curras-CollazoDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, California, USA.ORCID https://orcid.org/0000-0002-0189-4179

Funding

The Role of Midbrain to Prelimbic Cortex Glutamatergic projections in Stress-induced Drug SeekingU54MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI Emmanuel Antonio Cruz, Kenira J Thompson · 2019 to 2026
$35.9M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12RR003050 · NCRR · PONCE SCHOOL OF MEDICINE · PI ARMSTRONG, RAUL A · 1985 to 2011
$28.1M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI TORRES-RUIZ, JOSE A · 2012 to 2018
$15.9M
UC Riverside MARC U* Star Undergraduate Research ProgramT34GM062756 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2001 to 2022
$8.7M
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
Maternal Transfer of Oxytocin and Thyroid-disrupting Indoor Flame Retardants Affecting Offspring Social BrainF31ES034304 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KOZLOVA, ELENA V · 2023 to 2024
$83k
NCRR NIH HHS G12 RR003050NIEHS NIH HHS F31 ES034304NIEHS NIH HHS F31ES034304NIEHS NIH HHS R01 ES016099NIEHS NIH HHS R01ES016099NIGMS NIH HHS T34 GM062756NIH HHS 5T34GM062756NIH HHS T34GM062756NIMHD NIH HHS G12 MD007579NIMHD NIH HHS U54 MD007579
6 · The paper itself

Abstract

Polybrominated diphenyl ethers (PBDEs) are neuroendocrine-disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterized by abnormal psychosocial functioning and is commonly comorbid with cognitive deficits and sensory abnormalities. Here, we used a mouse model with translationally relevant exposure to establish direct causal evidence that maternal transfer of a commercial mixture of PBDEs, DE-71, produces ASD-relevant behavioral and neuroendocrine deficits in male offspring. C57Bl6/N mouse dams were exposed to a commercial PBDE mixture, DE-71, via oral administration of 0 (vehicle control, VEH/CON), 0.1 (L-DE-71), or 0.4 (H-DE-71) mg/kg b.w./day for 10 weeks, spanning from 3 weeks prior to gestation through the end of lactation at postnatal day (PND) 21. Mass spectrometric analysis indicated a dose-dependent transfer of PBDEs (in ppb) to brains of F1 male offspring at PND 30, with reduction in levels by PND 110. DE-71-exposed adult F1 male offspring displayed ASD-relevant abnormal neurobehavioral phenotypes, including impaired social novelty preference (SNP) despite intact general sociability and exaggerated repetitive behavior. There were also milder effects on long-term social recognition memory (SRM). DE-71-exposed mice also displayed altered olfactory discrimination of social odors without altered odor preference for non-social odors, impaired novel object recognition memory, and reduced open field habituation relative to VEH/CON. However, no changes were observed in sensorimotor, anxiety-, or depressive-like behaviors. At the molecular level, DE-71-exposed males displayed deregulated gene markers of prosocial neuropeptides, oxytocin, vasopressin, and PACAP systems in hypothalamic and forebrain regions. Oxt was upregulated in the paraventricular nucleus (PVN); Avp was upregulated in the PVN and bed nucleus of the stria terminalis (BNST) but downregulated in the lateral septum (LS); Avp1ar and Adcyap1 were upregulated in the BNST; and Adcyap1r1 was upregulated in the PVN, supraoptic nucleus (SON), and BNST. Peripheral OXT was increased in L-DE-71 males, while no changes in plasma AVP were observed. These findings demonstrate that developmental PBDE exposure produces enduring behavioral and neuroendocrine phenotypes that resemble core domains of ASD, which may result from early neurodevelopmental reprogramming within central social and memory networks.

Indexed as

Autistic DisorderFlame RetardantsHalogenated Diphenyl EthersHypothalamusPrenatal Exposure Delayed EffectsAnimalsBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLPhenotypePregnancySocial BehaviorFlame RetardantsHalogenated Diphenyl Ethersdevelopmental origins of health and disease (DOHaD)endocrine‐disrupting chemicalsneurodevelopmental disorderorganohalogensocial brain network

Identifiers

PMID42552960
PMCPMC13439164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.