Evidence map›Paper›PMID 42552926›Full record

ArticleClinical endoscopy2026

Utility of endoscopic ultrasonography elastography as a predictive tool for post-treatment recurrence of resectable pancreatic cancer treated with neoadjuvant and adjuvant chemotherapy: a retrospective study in Japan.

Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima

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Article in Clinical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yuichi KanoDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takuya IshikawaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kentaro YamaoDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yasuyuki MizutaniDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tadashi IidaDepartment of Endoscopy, Nagoya University Hospital, Nagoya, Japan.
Yoshihisa TakadaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takeshi YamamuraDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuhiro FurukawaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroki KawashimaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

JST (Moonshot R&D) JPMJMS2214-11
6 · The paper itself

Abstract

backgroundPost-treatment recurrence frequently occurs even in patients with resectable pancreatic cancer (PC) who receive neoadjuvant chemotherapy (NAC), surgery, and adjuvant chemotherapy (AC). This study aimed to evaluate whether endoscopic ultrasonography elastography (EUS-EG) of PC lesions is useful in predicting post-treatment recurrence in such patients.

methodsWe retrospectively analyzed 44 of 164 consecutive patients with resectable PC who underwent NAC, surgery, and AC after EUS-EG. The endpoints were associations between EUS-EG stiffness classification (soft/stiff) and pathological response, post-treatment recurrence, and recurrence-free survival (RFS).

resultsIn the soft vs. stiff groups, the median pathological response rate was 30% (20%-75%) vs. 20% (10%-65%) (p=0.022), post-treatment recurrence rate was 25% vs. 59% (p=0.042), and the median RFS was NR (not reached) days vs. 683 days (p=0.039). In the multivariate analysis, stiffness classification was the only factor significantly associated with RFS (hazard ratio, 4.2; p=0.025).

conclusionsTo the best of our knowledge, this is the first study to indicate that EUS-EG stiffness classification may predict recurrence in resectable PC treated with NAC, surgery, and AC. Patients with stiff lesions on EUS-EG tend to have a higher risk of recurrence and may require more careful post-treatment follow-up and novel treatment strategies.

Indexed as

Adjuvant chemotherapyElasticity imaging techniquesEndoscopic ultrasonographyNeoadjuvant therapyPancreatic neoplasmsRecurrence

Identifiers

PMID42552926
PMCPMC13439298

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