Evidence map›Paper›PMID 42552767›Full record

ArticleMovement disorders clinical practice2026

Longitudinal Associations between Depression, Daytime Sleepiness, and Caregiver Strain in Parkinson's Disease.

Sarah Holden, Sean P Lane, Madison Christopher, Lisa Mann, Julie H Carter, Joseph Quinn, Jiayun Xu

Abstract read
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sarah HoldenParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.ORCID https://orcid.org/0009-0004-9144-6901
Sean P LaneDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Madison ChristopherParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.
Lisa MannParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.
Julie H CarterParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.
Joseph QuinnParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.
Jiayun XuParkinson Center, Oregon Health & Sciences University, Portland, OR, USA.

Funding

Toward a Generalized Framework and Flexible Software Environment for Power Analysis of Alcohol Treatment Randomized Controlled TrialsR01AA027264 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI HENNES, ERIN, LANE, SEAN P · 2018 to 2022
$3.4M
Preparing Patient-Caregiver Dyads with Parkinson's Disease for End-of-Life Decision MakingK23NR019099 · NINR · PURDUE UNIVERSITY · PI XU, JIAYUN · 2021 to 2023
$495k
NIAAA NIH HHS R01 AA027264NIAAA NIH HHS R01AA027264NINR NIH HHS K23 NR019099NINR NIH HHS K23NR019099
6 · The paper itself

Abstract

objectiveExamine the longitudinal relationship between caregiver strain and Parkinson's patient depression, daytime sleepiness, and treatment with dopamine agonists and antidepressants.

backgroundParkinson's disease (PD) is a neurodegenerative disorder, in which family caregivers play an integral role in patient care. Depression and daytime sleepiness in PD patients have been shown to influence caregiver strain.

methodsThis study was a longitudinal analysis of PD patient sleep and depression measures, and a measure of caregiver strain. Strain scores were modeled as a function of: accumulated time between visits, PD patient depression and sleep scores, and their interactions with time.

resultsCaregiver strain increased over time, with patient depression and daytime sleepiness positively associated with greater caregiver strain.

conclusionsPatient depressive symptoms consistently predicted caregiver strain, highlighting the central role of patient depression in caregiver well-being. Routine caregiver evaluations during patient visits facilitate timely interventions that benefit patients and caregivers.

Indexed as

caregiver burdencaregiver well‐beingfamily caregivinglongitudinal analysisquality of life

Identifiers

PMID42552767
PMCPMC13439032

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.