ArticleSmall methods2026
Single-Nanoparticle Detection Using Quasi-Bound States in the Continuum Supported by Silicon Metasurfaces.
Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The detection of single particles or molecules represents a critical milestone in the development of biosensing technologies. Optical sensors based on quasi-bound states in the continuum (qBICs) have primarily focused on detecting global refractive index changes, whereas detection of local refractive index perturbations, such as the binding of a nanometer-sized molecule on a surface, remains elusive because of limited quality (Q) factors and relatively large mode volumes. Here, we demonstrate low-contrast BIC metasurfaces that can perform sensing with a virus-sized single-nanoparticle resolution. The qBIC resonance operating at the critical coupling condition exhibits an experimental Q factor of 4.5 × 10
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