SynthesisTrends in hearing
Reinterpreting the Frequency Dependence of Cortical Auditory-Evoked Response Amplitudes in Light of Current Understanding of Cortical Tonotopic Organization.
Synthesis in Trends in hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Tonotopy is a fundamental feature of auditory cortical organization, yet its influence on cortical auditory-evoked responses (AERs) remains unclear. Consequently, key properties of cortical AERs-such as their marked amplitude reduction with increasing stimulus frequency-still lack a coherent mechanistic explanation. To address this gap, we combined a meta-analysis of frequency-specific AER amplitudes with forward simulations of AERs informed by current knowledge of auditory cortical tonotopic layout and functional organization. The meta-analysis used a semi-systematic search covering all known automatic cortical AER components-both transient-evoked and steady-state-along with selected subcortical components for comparison. Forward simulations were based on a functional parcellation of the human supratemporal auditory region into subdivisions forming distinct tonotopic maps, and an idealized model of each division's intrinsic tonotopic layout. Parcellation was achieved using a novel, largely automated procedure applied to high-field (3 T) and ultra-high-field (7 T) functional and microstructural MRI mapping data from 30 individual hemispheres. Meta-analytic results revealed that, whilst all cortical AER components consistently show frequency-related amplitude reduction, reduction is greater in steady-state compared to transient-evoked components. Simulations indicated that frequency-related amplitude reduction arising from cortical morphology is confined to the highly myelinated central portion of Heschl's gyrus, suggesting that differences in reduction amount between steady-state and transient-evoked components may reflect differences in the relative strengths of their primary contributions. Our findings provide a new perspective on cortical AER generation. They represent an important step toward explaining morphology-related variability in AER amplitudes and establishing a quantitative link to underlying source strengths.
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