Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short-Term Spatial Memory via Multiple Ionic and Signaling Mechanisms.

Chidiebele S Oraegbuna, Phani K Kola, Simon L Griggs, Saobo Lei

Abstract read

In one paragraph

Article in Advanced biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chidiebele S OraegbunaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.ORCID https://orcid.org/0009-0004-4459-5365

Phani K KolaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.ORCID https://orcid.org/0000-0002-1833-7811

Simon L GriggsDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.ORCID https://orcid.org/0009-0009-4567-0386

Saobo LeiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.ORCID https://orcid.org/0000-0002-3882-0253

Funding

Cellular and molecular mechanisms of vasopressin in anxietyR01MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2023

$1.5M

Cellular and molecular mechanisms of vasopressin in anxietyR56MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2019

$232k

NIDA NIH HHS MH118258NIGMS NIH HHSNIMH NIH HHS R01 MH118258NIMH NIH HHS R56 MH118258

6 · The paper itself

Abstract

Ghrelin is the endogenous ligand of the ghrelin secretagogue receptors (GHSRs). Although the GHSRs are densely expressed in the dentate gyrus (DG) granule cells (GCs), their roles in the DG GCs remain to be fully understood. We probed the actions of ghrelin on the DG GCs with whole-cell recordings and its effects on short-term spatial memory using the Y-maze spontaneous alternation test. Application of ghrelin excited the DG GCs by depressing the G protein-coupled inwardly rectifying K

Indexed as

Dentate GyrusGhrelinMemory, Short-TermNeuronsReceptors, GhrelinSignal TransductionSpatial MemoryAction PotentialsAnimalsCyclic AMPGuanine Nucleotide Exchange FactorsMaleRatsCyclic AMPGhrelinGuanine Nucleotide Exchange FactorsReceptors, Ghrelinglutamatememoryreceptorsignalsynapsetransmitter

Identifiers

PMID42552604

DOI10.1002/adbi.70145

PMCPMC13437931

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.