Evidence map›Paper›PMID 42552600›Full record

ArticleAdvanced biology2026

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium.

Mengyu Li, Zhenyuan Guo, Yuwei Jiang, Lianghao Zhao, Yuxiang Zhang, Lingxin Meng, Chengzhi Ni, Zhiqiang Chen, Lu Zhang

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In one paragraph

Article in Advanced biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mengyu LiCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Zhenyuan GuoCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Yuwei JiangCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Lianghao ZhaoCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Yuxiang ZhangCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Lingxin MengCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Chengzhi NiCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Zhiqiang ChenCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.
Lu ZhangCollege of Bioengineering, Henan University of Technology, Zhengzhou, China.ORCID https://orcid.org/0000-0003-4085-2980

Funding

Double First-Class Discipline Construction Program of Henan University of Technology HAUTSYL2023KC05Innovative Funds Plan of Henan University of Technology 2021ZKCJ16National Natural Science Foundation of China 32070742National Natural Science Foundation of China 32400624National Natural Science Foundation of Henan province 232300421030
6 · The paper itself

Abstract

Aging involves the progressive decline of cellular function, yet the key molecular regulators that determine aging require further identification. Building on our previous finding that the intracellular domain of CD44 (CD44ICD) is a critical aging regulator, we performed an interactome screen to identify its functional partners. This approach revealed BCAP31 and POLR1E as two previously unrecognized modulators of senescence. Depletion of their respective orthologs in Caenorhabditis elegans (C. elegans) shortened lifespan and accelerated age-related functional decline. In human vascular endothelial cells, knockdown of BCAP31 or POLR1E induced premature cellular senescence, whereas their overexpression countered it. Importantly, the protein levels of both BCAP31 and POLR1E decreased during physiological aging across species, including in senescent endothelial cells, aged nematodes, and tissues from old mice, with BCAP31 reduction being particularly pronounced in the cardiovascular system. Our findings establish BCAP31 and POLR1E as evolutionarily conserved components of a CD44-associated network that protects against cellular senescence and organismal aging, highlighting new potential targets for mitigating age-related vascular decline.

Indexed as

AgingCaenorhabditis elegansCaenorhabditis elegans ProteinsCellular SenescenceEndothelium, VascularAnimalsHumansMiceCaenorhabditis elegans ProteinsagingBCAP31C. elegansPOLR1Evascular endothelial cells

Identifiers

PMID42552600
PMCPMC13437924

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.