ArticleNature plants2026
The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions.
Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- ULTRA(PETALA)-boosted plant Polycomb.Nature plants · 2026Article
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22 authors.
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Abstract
The antagonistic POLYCOMB (PcG) REPRESSIVE COMPLEX 2 (PRC2) and trithorax (trxG) chromatin machineries orchestrate gene expression during the development of multicellular eukaryotes. These complexes deposit and maintain the repressive trimethyl mark on H3K27 and the activating trimethyl mark on H3K4, respectively. However, the mechanisms governing the switch between these functions remain elusive, especially in plants, whose lifelong, flexible development relies heavily on this process. Here we demonstrate that the plant-specific ULTRAPETALA1 (ULT1) protein, previously reported as a trxG factor antagonizing the PRC2 enzymatic subunit CURLY LEAF (CLF), also exhibits a pro-PRC2 function, increasing H3K27 trimethylation levels at over 1,000 genes. We discovered that ULT1 physically interacts with PRC2 components, particularly the SWINGER (SWN) enzymatic subunit, and that in vitro it significantly enhances the enzymatic activity of PRC2
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