Evidence map›Paper›PMID 42552416›Full record

ArticlePediatric research2026

Comparison of the predictive ability for PDA surgery between early serum NT-proBNP level and echocardiographic PLASE score.

Yusuke Morita, Satoshi Masutani, Kyongsun Pak, Natsumi Banno, Yoshihiko Taniyama, Kaoru Katsumata, Takahiro Noguchi, Yoshinori Inagaki, Tomoko Saito, Tomoyuki Shimokaze and 5 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Yusuke MoritaDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Satoshi MasutaniDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan. masutani@saitama-med.ac.jp.
Kyongsun PakDepartment of Data Science, Clinical Research Center, National Center for Child Health and Development, Setagaya, Japan.
Natsumi BannoDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Yoshihiko TaniyamaDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Kaoru KatsumataDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Takahiro NoguchiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Yoshinori InagakiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Tomoko SaitoDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Tomoyuki ShimokazeDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Jun ShibasakiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Seiichi TomotakiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tohru KobayashiDepartment of Data Science, Clinical Research Center, National Center for Child Health and Development, Setagaya, Japan.
Tetsuya IsayamaDepartment of Neonatology, National Center for Child Health and Development, Setagaya, Japan.
Katsuaki ToyoshimaDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough serum NT-proBNP is a useful marker of patent ductus arteriosus (PDA) severity in the early postnatal period, its ability to predict the future need for PDA surgery remains unclear. This study aimed to compare the predictive abilities of early NT-proBNP and the PLASE score using an established echocardiographic model.

methodsInfants born at 23-29 weeks of gestation between 2019 and 2024 and admitted to a tertiary neonatal intensive care unit were included. Serum NT-proBNP levels and echocardiographic indices at 3 days of age were retrospectively collected. Three predictive models were evaluated: Model 1, the PLASE score (reference); Model 2, log

resultsAmong 126 infants included, 23 (18%) underwent PDA surgery. The ROC-AUCs (95% CI) were 0.829 (0.748-0.910) for Model 1, 0.669 (0.539-0.798) for Model 2, and 0.826 (0.741-0.911) for Model 3. Model 1 yielded higher ROC-AUC than Model 2 (p = 0.02), whereas no significant difference was observed between Model 1 and Model 3 (p = 0.94).

conclusionsEarly postnatal NT-proBNP combined with gestational age showed high predictive ability comparable to the PLASE score. NT-proBNP could be used to estimate the likelihood of future PDA surgery. IMPACT: N-terminal pro-B-type natriuretic peptide (NT-proBNP) measured at 3 days of age, when combined with gestational age, demonstrated high predictive ability for patent ductus arteriosus (PDA) surgery (Area under the receiver operating characteristic curve: 0.826). Early postnatal NT-proBNP yielded results equivalent to those of the PLASE score, an echocardiographic prediction model. This study suggests that early NT-proBNP assessment may complement echocardiographic evaluation in the management of PDA.

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PMID42552416

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