Evidence map›Paper›PMID 42552388›Full record

Reviewnpj health systems2026

Designing clinical AI for patient-centered support beyond the visit: the PACT framework for health systems.

Saif Khairat, Charles Safran

Abstract readReview
In one paragraph

Review in npj health systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Saif KhairatCarolina Health Informatics Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Saif@unc.edu.
Charles SafranHarvard Medical School, Boston, MA, USA.

Funding

Center for Virtual Care Value and Excellence (ViVE). RC2TR004380 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Saif Khairat · 2023 to 2026
$3.0M
Evaluating Nurse Demands and Resources with Virtual Nursing to Mitigate BurnoutR01NR021711 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Saif Khairat · 2026 to 2026
$742k
NCATS NIH HHS RC2 TR004380NCATS NIH HHS RC2TR004380NINR NIH HHS R01 NR021711
6 · The paper itself

Abstract

Clinical AI has advanced rapidly for bounded in-visit tasks such as prediction, documentation, and message generation, yet many costly failures in care occur outside the encounter when follow-up, handoffs, and communication break down. We argue that the next challenge for clinical AI is not only better task performance, but better operational follow-through across the care journey. We propose the PACT framework (Patient-centered, AI-enabled Continuity and Timely action) that reframes clinical AI as a health system function designed to support continuity, completion, escalation, and equity across pre-visit, visit, and post-visit care. The PACT framework specifies the operational elements required for accountable action, including ownership, communication channels, confirmation rules, escalation pathways, and outcome measures. We illustrate its practical use through post-visit coordination, a high-impact setting in which health systems can test workflow integration, monitoring, and tiered human support.

Identifiers

PMID42552388
PMCPMC13438703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.