Evidence map›Paper›PMID 42552386›Full record

ArticleNature genetics2026

High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk.

Valeriya Malysheva, Helen Ray-Jones, Nora Lakes, Rachel A Brown, Tareian A Cazares, Owen Clay, David E Ohayon, Pavel Artemov, Joseph A Wayman, Zi F Yang and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Valeriya Malysheva *MRC Laboratory of Medical Sciences, London, UK. valeriya.malysheva@vib.be.ORCID http://orcid.org/0000-0002-0919-7845
Helen Ray-Jones *MRC Laboratory of Medical Sciences, London, UK.
Nora Lakes *Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rachel A BrownDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Tareian A CazaresImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Owen ClayDivision of Human Genetics and Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
David E OhayonDivision of Human Genetics and Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pavel ArtemovMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0001-6699-6400
Joseph A WaymanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Zi F YangDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Monica Della RosaMRC Laboratory of Medical Sciences, London, UK.
Carmen PetitjeanMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0002-7687-4447
Clarissa BoothCenter for Genetics and Rare Diseases, Sanford Research, Sioux Falls, SD, USA.
Joseph I J EllawayMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0002-6670-5391
Jenna R BarnesMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andrew W DangelDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Ankita SainiDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0009-0000-3694-495X
William R OrchardMRC Laboratory of Medical Sciences, London, UK.
Xiaoting ChenDivision of Human Genetics and Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-3782-3962
Sreeja ParameswaranDivision of Human Genetics and Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Frances BurdenDepartment of Haematology, University of Cambridge, Cambridge, UK.
Mattia FrontiniDepartment of Haematology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8074-6299
Takashi NaganoThe Babraham Institute, Cambridge, UK.
Peter FraserThe Babraham Institute, Cambridge, UK.
Stefan SchoenfelderThe Babraham Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3200-8133
Matthew T WeirauchImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-7977-9122
Leah C KottyanImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-3979-2220
David F SmithDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-0048-4012
Nick PowellDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3231-6950
Jill M WeimerCenter for Genetics and Rare Diseases, Sanford Research, Sioux Falls, SD, USA.
Eugene M OltzDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Chris WallaceMRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge Institute of Public Health, Cambridge, UK.ORCID http://orcid.org/0000-0001-9755-1703
Emily R MiraldiImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-0232-3116
Stephen N WaggonerImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA. stephen.waggoner@cchmc.org.ORCID http://orcid.org/0000-0001-9658-2874
Mikhail SpivakovMRC Laboratory of Medical Sciences, London, UK. mikhail.spivakov@lms.mrc.ac.uk.ORCID http://orcid.org/0000-0002-0383-3943

Funding

RCUK | Medical Research Council (MRC) MC-A652-5QA20
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4

Indexed as

Immunity, InnateLymphocytesPromoter Regions, GeneticAnimalsCD4-Positive T-LymphocytesCrohn DiseaseGene Expression RegulationGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMice

Identifiers

PMID42552386
PMCPMC13447110

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.