ArticleInternational journal of obesity (2005)2026
Selected biomarkers of coagulation, inflammation, and vascular tone in young women with normal weight obesity.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Quantifying the Association Between Obesity and In-Hospital Outcomes in Adult Scoliosis Surgery: A Nationwide Inpatient Sample Analysis (2016-2021).Journal of clinical medicine · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
Individuals with the Normal Weight Obesity (NWO) phenotype are characterized by excessive body fat despite normal Body Mass Index (BMI), often leading to underestimated cardiovascular risk. The mechanisms linking this specific body composition to early vascular damage remain unclear. The aim of this study was to evaluate endothelial dysfunction biomarkers in young women with NWO, and to identify the main axes of vascular impairment. The study included 176 young women (median age 20) with normal BMI (18.5-24.9 kg/m²). Based on dual-energy X-ray absorptiometry (DXA), participants were classified into an NWO group (n = 88; percent body fat (PBF) ≥ 35.8%) and a healthy control group (NW; n = 88). Serum levels of tissue-type plasminogen activator (tPA), von Willebrand factor (vWF), Angiopoietin-1 (Ang-1), Nitric Oxide (NO), and high-sensitivity C-reactive protein (hs-CRP) were analyzed. Principal Component Analysis (PCA) was employed to identify latent patterns of endothelial function. Women with NWO exhibited significantly higher levels of tPA (1.86 vs. 1.48 ng/ml; p = 0.038), vWF (72.24 vs. 63.62 ng/ml; p = 0.038), and Ang-1 (515.3 vs. 491.63 pg/ml; p = 0.008) compared to controls. PCA identified three principal components explaining 71.68% of the total variance: Coagulation (tPA, vWF), Inflammation/Angiogenesis (hs-CRP, Ang-1), and Vasodilation (NO). Young women with NWO exhibit subclinical endothelial dysfunction, which is characterized primarily by a pro-thrombotic state and disturbed angio-inflammatory balance. These changes occur even before the onset of overt metabolic or cardiovascular disease.
Identifiers
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Registered trials
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