Evidence map›Paper›PMID 42551848›Full record

ArticlePaediatric and perinatal epidemiology2026

Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes.

Lindsey M Russo, J Richard Pilsner, Timothy P Canty, Neil J Perkins, Pauline Mendola, Karen C Schliep, May Shaaban, Rachael B Hemmert, Akanksha Singh, Allison M Ring and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01857310 (Folic Acid and Zinc Supplementation Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01857310 nacompletednot on this map

Folic Acid and Zinc Supplementation Trial: A Multi-center, Double-blind, Block-randomized, Placebo-controlled Trial

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2013 to 2019Enrolled2,370ConditionsPregnancy, Live Birth, Spontaneous AbortionArms5 mg folic acid and 30 mg elemental zinc, Placebo Comparator: Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lindsey M RussoDivision of General Internal Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-7639-8655
J Richard PilsnerDepartment of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-4541-6267
Timothy P CantyDepartment of Atmospheric and Oceanic Science, University of Maryland, College Park, Maryland, USA.ORCID https://orcid.org/0000-0003-0618-056X
Neil J PerkinsBiostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Pauline MendolaEpidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA.ORCID https://orcid.org/0000-0001-5330-2844
Karen C SchliepDivision of Public Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-1771-3157
May ShaabanDivision of Public Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Rachael B HemmertDivision of Public Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Akanksha SinghDepartment of Atmospheric and Oceanic Science, University of Maryland, College Park, Maryland, USA.
Allison M RingDepartment of Atmospheric and Oceanic Science, University of Maryland, College Park, Maryland, USA.
James A VandersliceDivision of Public Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, Utah, USA.
C Matthew PetersonDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Erica B JohnstoneDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Kaniz RabeyaDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID https://orcid.org/0009-0003-0176-3480
Carrie NoblesDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2182-8486

Funding

Exposure to Ambient Air Pollution and Temperature During Spermatogenesis: Impact on Men's Reproductive Health and Infertility Treatment OutcomesK01ES034005 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI NOBLES, CARRIE · 2022 to 2024
$438k
Eunice Kennedy Shriver National Institute of Child Health and Human Development HHSN275201200007CEunice Kennedy Shriver National Institute of Child Health and Human Development HHSN275201300026NIEHS NIH HHS K01-ES034005NIEHS NIH HHS K01ES034005
6 · The paper itself

Abstract

backgroundMale preconception health remains a critically under-addressed area of family planning. While research suggests air pollution may harm semen quality, downstream impacts on pregnancy, particularly for more vulnerable infertility treatment populations, are understudied.

objectivesAmong couples seeking infertility treatment, we examined the relationship between men's exposure to ambient air pollution and intrauterine insemination (IUI) cycle treatment outcomes.

methodsIn the Folic Acid and Zinc Supplementation Trial (2013-2018), 592 male partners resided in the Salt Lake City area with at least one IUI cycle in 9 months of follow-up (n = 1223 cycles). Residential air pollution exposure was estimated using Community Multiscale Air Quality models and averaged across the 74-day window of spermatogenesis prior to the insemination date, as well as across developmental windows of mitosis, meiosis I-II, spermiogenesis, and spermiation. Treatment-cycle probabilities of hCG+ pregnancy, pregnancy loss, and livebirth were evaluated using generalised linear mixed models adjusted for age, season, income, and co-pollutants (fine particulate matter [PM

resultsIn multivariable models, we observed a lower probability of pregnancy per 5 ppb increase in O

conclusionsAmbient air pollution during spermatogenesis, especially during mitosis and meiosis, was associated with a lower chance of pregnancy and live birth in an IUI treatment population. Further understanding pathways between men's air pollution exposure and pregnancy and live birth is an important future research need.

trial registrationclinicaltrials.gov identifier: NCT01857310.

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureInfertility, MaleInsemination, ArtificialSpermatogenesisAdultFemaleHumansMaleMulticenter Studies as TopicParticulate MatterPregnancyPregnancy OutcomeRandomized Controlled Trials as TopicAir PollutantsParticulate Matterair pollutionenvironmentinfertility treatmentintrauterine insemination outcomesspermatogenesissubfertility

Identifiers

PMID42551848
PMCPMC13624516

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.