ArticleBiofabrication2026
Gravity-driven microfluidic synthesis of lipid nanoparticles via vibrating sharp-tip mixing.
Article in Biofabrication, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Lipid nanoparticles (LNPs) are widely used in nanomedicine, yet their energy-efficient manufacture with precise control over particle uniformity remains challenging. Here we report a gravity-driven microfluidic platform that integrates acoustically actuated sharp-tip mixing to enable high-throughput LNPs synthesis without the need for active pumps. By optimizing microchannel geometry, actuation conditions, and the spatial positioning of the mixing vortex, we achieve stable gravity-driven flow and complete mixing at total flow rates (TFRs) of up to 5 ml min
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