Evidence map›Paper›PMID 42551253›Full record

ArticleDrug and alcohol dependence2026

Prediction of alcohol consumption: The role of genetics, impulsivity, and sensation seeking from adolescence to adulthood.

Lilia G Geel, Robin P Corley, Chandra A Reynolds, Sandra Sanchez-Roige, 23andMe Research Team, Soo H Rhee, Daniel E Gustavson

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lilia G GeelInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Electronic address: lilia.geel@colorado.edu.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Chandra A ReynoldsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
23andMe Research Team23andMe Research Institute, Palo Alto, CA 94306, USA.
Soo H RheeInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Daniel E GustavsonInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.

Funding

Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5M
Understanding the links between parental and adolescent substance use:complementary natural experiments using the children of twins designR01DA054087 · NIDA · UNIVERSITY OF COLORADO · PI Matthew Charles Keller, SOO H RHEE · 2022 to 2026
$4.9M
Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental DatasetsR01DA059804 · NIDA · UNIVERSITY OF COLORADO · PI Daniel Gustavson · 2024 to 2026
$2.0M
Implications of midlife alcohol use for risk of dementia in male and female twins: Unique contributions and interactions with APOE4R21AG087486 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E · 2024 to 2024
$469k
NIA NIH HHS R01 AG046938NIA NIH HHS R21 AG087486NIDA NIH HHS R01 DA054087NIDA NIH HHS R01 DA059804
6 · The paper itself

Abstract

backgroundThere are well-known phenotypic and genetic associations among impulsivity, sensation seeking (SS), and alcohol consumption, but whether they vary between adolescence and early adulthood remains unclear. PURPOSE/HYPOTHESES: We hypothesized that adolescent alcohol consumption would be better predicted by polygenic indices (PGIs) of impulsivity and SS than PGIs of adult alcohol consumption (drinks per week; DPW), but that the reverse would be observed in young adulthood (i.e., stronger associations for DPW PGIs).

methodsN = 733-754 twins of European genetic ancestry from the Colorado Longitudinal Twin Study were assessed at age 17 and/or 23 years using structural equation modeling.

resultsThe SS PGIs were associated with alcohol consumption in adolescence (β=0.16), whereas DPW PGIs were associated with alcohol consumption in early adulthood (β=0.15). Additionally, phenotypic measures of impulsivity and SS are associated with alcohol consumption at both ages (β=.13-.21) and mediated some PGI-alcohol associations. DISCUSSION: These findings suggest that genetic influences on alcohol consumption change from adolescence to early adulthood, with genetic influences on sensation seeking most relevant to alcohol consumption in adolescence.

Indexed as

Alcohol DrinkingImpulsive BehaviorAdolescentFemaleGenetic Risk ScoreHumansLongitudinal StudiesMaleYoung AdultAdolescenceAlcohol consumptionBehavior geneticsImpulsivitySensation seeking

Identifiers

PMID42551253
PMCPMC13688944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.