In one paragraphArticle in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
74 authors.
Philip S NashUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0003-2428-1575 Jonathan G BestUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0002-4243-5753 Duncan WilsonUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0002-4479-6974 Houwei DuUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0002-5978-9734 Rustam Al-Shahi SalmanInstitute for Neuroscience and Cardiovascular Research at the University of Edinburgh, United Kingdom.ORCID 0000-0002-2108-9222 Hans Rolf JägerUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0002-6403-4184 Gregory Y H LipLiverpool Centre for Cardiovascular Science at the University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, United Kingdom.ORCID 0000-0002-7566-1626 Martina B GoeldlinDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0001-5800-116X Morin BeyelerDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0001-5911-7957 Philipp BückeDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0001-5204-2016 Marwan El-KoussyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Inselspital Bern, University of Bern, Switzerland.
Heinrich P MattleDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0001-7968-1731 Leonidas PanosDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0002-5372-1819 Dianne H K van Dam-NolenDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
Florian DubostBiomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID 0000-0002-7035-2680 Jeroen HendrikseDepartment of Radiology, University Medical Centre Utrecht, Utrecht University, the Netherlands.ORCID 0000-0001-6384-6140 M Eline KooiDepartment of Radiology and Nuclear Medicine, CARIM Cardiovascular Research Institute Maastricht, Maastricht University Medical Center (MUMC+), the Netherlands.ORCID 0000-0001-7562-5724 Werner H MessDepartment of Clinical Neurophysiology, Maastricht University Medical Centre, the Netherlands.ORCID 0000-0002-9736-9941 Paul J NederkoornDepartment of Neurology, Amsterdam University Medical Centres, Location AMC, the Netherlands.ORCID 0000-0001-7386-4545 Nicolas ChristDepartment of Neurology, University Hospital of Würzburg, Germany.
Sarah GunkelDepartment of Neurology, University Hospital of Würzburg, Germany.
Christopher Charles KarayiannisPeninsula Clinical School, Peninsula Health, Monash University, Melbourne, Australia.ORCID 0000-0001-8301-7171 John LyStroke and Ageing Research Group, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.ORCID 0000-0002-9962-4766 Shaloo SinghalStroke and Ageing Research Group, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.ORCID 0000-0003-4348-5979 Keon-Joo LeeDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.ORCID 0000-0002-6571-7091 Jae-Sung LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-6157-2908 Hideo HaraDivision of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Japan.ORCID 0000-0003-3289-3555 Jun TanakaDivision of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Japan.
Masaaki YoshikawaDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.ORCID 0000-0001-5318-9431 Derya Selcuk DemirelliDivision of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Japan.ORCID 0000-0003-4148-207X Zeynep TanriverdiDepartment of Radiology, Saga University Faculty of Medicine, Nabeshima, Japan.
Ender UysalDepartment of Neurology, Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Shelagh B Couttsİzmir Katip Çelebi University Atatürk Education and Research Hospital Department of Neurology, Izmir, Turkey.ORCID 0000-0001-5090-5105 Francesca M ChappellSaglık Bilimleri University Sisli Etfal Education and Research Hospital Department of Radiology, Istanbul, Turkey.ORCID 0000-0002-7742-1757 Stephen Dj MakinCentre for Clinical Brain Sciences, Edinburgh Imaging, University of Edinburgh, United Kingdom.ORCID 0000-0001-8701-9043 Debbie Y K WongInstitute of Applied Health Sciences, University of Aberdeen, United Kingdom.
Jill AbrigoDepartment of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Switzerland.ORCID 0000-0001-5238-709X Winnie Cw ChuDepartment of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Switzerland.ORCID 0000-0003-4962-4132 Daniel BosDepartment of Neurology, University Hospital Inselspital Bern, University of Bern, Switzerland.ORCID 0000-0001-8979-2603 Felix FluriDepartment of Clinical Neurophysiology, Maastricht University Medical Centre, the Netherlands.ORCID 0000-0002-2595-5431 Velandai K SrikanthDepartment of Neurology, Amsterdam University Medical Centres, Location AMC, the Netherlands.ORCID 0000-0002-8442-8981 Ji Hoe HeoStroke and Ageing Research Group, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.ORCID 0000-0001-9898-3321 Yusuke YakushijiDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-3206-6939 Dilek Necioglu OrkenDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0002-1118-5309 Eric E Smithİzmir Katip Çelebi University Atatürk Education and Research Hospital Department of Neurology, Izmir, Turkey.ORCID 0000-0003-3956-1668 Joanna M WardlawSaglık Bilimleri University Sisli Etfal Education and Research Hospital Department of Radiology, Istanbul, Turkey.ORCID 0000-0002-9812-6642 Robert J SimisterUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0003-0578-6711 David C WheelerNeurology and Neurorehabilitation, University Department of Geriatric Medicine FELIX PLATTER, University of Basel, Switzerland.ORCID 0000-0003-0745-3478 David J WerringUCL Stroke Research Centre, Department of Translational Neuroscience and Stroke, University College London Queen Square Institute of Neurology, United Kingdom.ORCID 0000-0003-2074-1861 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
BACKGROUND AND
objectivesEnlarged perivascular spaces (EPVSs) in the basal ganglia (BG-EPVS) are an important marker of cerebral small vessel disease (cSVD), and EPVS in the centrum semiovale (CSO-EPVS) are part of the diagnostic criteria for cerebral amyloid angiopathy. We aimed to investigate associations of EPVS with reduced estimated glomerular filtration rate (eGFR) and glomerular hyperfiltration (higher than normal eGFR), which have scarcely been studied previously.
methodsIn this cross-sectional study, we used pooled individual patient data from the Microbleeds International Collaborative Network which includes patients with ischemic stroke or transient ischemic attack. We investigated associations of impaired kidney function, defined as an eGFR of 30-60 or <30 mL/minute/1.73 m
resultsSeven thousand two hundred fifty-four patients (mean age 71 ± 13 years, 43% female) were included in the analysis, 357 with glomerular hyperfiltration, 1,692 with eGFR 30-60, and 256 with eGFR <30. Compared with normal glomerular filtration, hyperfiltration was independently associated with BG-EPVS (adjusted odds ratio [aOR] 1.38, 95% CI 1.11-1.70, DISCUSSION: Glomerular hyperfiltration was independently associated with EPVS severity, in both the basal ganglia and centrum semiovale. eGFR <30 was independently associated with total cSVD burden. A key limitation was a lack of repeated eGFR measurements.
Indexed as
Basal GangliaCerebral Small Vessel DiseasesGlomerular Filtration RateGlymphatic SystemKidneyAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle Aged
Identifiers
PMID42551001
PMCPMC13445499
What OpenQuestion holds
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