Evidence map›Paper›PMID 42550907›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

DENV-4 infection suppresses transcription of DNA repair genes.

Erica N Lamkin, Jessica Reich, Josh A Victor, Madison Guyette, Naveen Kothandaraman, Vihit Gupta, Alfred T Harding, Tristan X Jordan, Lee Gehrke, Pei Zhou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erica N Lamkin *Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Jessica Reich *Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Josh A Victor *Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Madison GuyetteDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.ORCID 0009-0006-6084-5787
Naveen KothandaramanDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Vihit GuptaDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.ORCID 0009-0008-9007-165X
Alfred T HardingInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02138.
Tristan X JordanDepartment of Microbiology, University of Washington, Seattle, WA 98109.
Lee GehrkeInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02138.ORCID 0000-0002-9387-8212
Pei ZhouDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0002-7823-3416
Benjamin tenOeverDepartment of Microbiology, New York University Grossman School of Medicine, New York City, NY 10016.ORCID 0000-0003-0324-3078
Nimrat ChatterjeeDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.ORCID 0000-0001-6556-9423

Funding

Virology Core: MIT Center for Human Tissue Models for Infectious Diseases (MIT.HTMID)U19AI131135 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2017 to 2021
$8.7M
Mechanistic insights into translesion synthesis-dependent genome instabilityR35GM150992 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Nimrat Chatterjee · 2023 to 2026
$1.5M
NIAID NIH HHS U19 AI131135NIGMS NIH HHS R35 GM150992Start-up funds NCUVMCC Grant Incentive Program NC
6 · The paper itself

Abstract

The molecular mechanisms behind Dengue virus-dependent host pathogenesis, especially genome instability, remain largely unclear. This RNA virus causes a debilitating disease during active infection and presents future risks of postdengue syndromes, leukemia, and DNA damage in the blood cells of infected patients, with the underlying mechanisms unknown. In this study, we show that DENV-4 infection induces significant DNA damage and suppresses the transcription of genes involved in DNA repair and select mutagenic translesion synthesis (TLS) polymerases, indicating that DENV-4-dependent pathobiology leaves durable biological "scars" that incrementally increase chronic disease risk, including carcinogenesis and postdengue syndromes.

Indexed as

DengueDengue VirusDNA RepairTranscription, GeneticDNA DamageGenomic InstabilityHumansTranslesion DNA SynthesisdengueDENV-4DNA repairgenome instabilitytranslesion synthesis

Identifiers

PMID42550907
PMCPMC13462168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.