ArticleProceedings of the National Academy of Sciences of the United States of America2026
Cytoplasmic fluidity couples nutrient availability and enterocyte fate in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cells must continuously adapt their internal state to fluctuating nutritional environments. For the adaptation, cells sense distinct nutrients through specific molecular signals, such as the insulin and mTOR pathways. Here, in addition to the conventional nutrient-sensing mechanisms, we reveal a mechanistic layer by which gut enterocytes respond to dietary contents, demonstrating that nutritional components in food regulate cytoplasmic fluidity, a fundamental biophysical property and determine cellular status. We found that the quantity, rather than the quality, of amino acids alters the nanoscale cytoplasmic fluidity in
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