ArticleEJNMMI radiopharmacy and chemistry2026
Stable core-encapsulation of indium-111 in crosslinked polyionic complex micelles and assessment of its biodistribution.
Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRadioactive isotopes, such as Indium-111 (
resultsDOTA-functionalized PICm were fabricated through electrostatic self-assembly of PEG-based polymers and subsequent core crosslinking. The resulting micelles exhibited a highly uniform size (32.6 ± 6.3 nm) and a modestly negative surface charge (- 4.9 ± 1.0 mV). Stability assays demonstrated that under the acidic conditions required for
conclusionsThe core-loading of PICm may offer advantages over surface-chelated nanocarriers. By maintaining structural integrity during radiolabeling and extending systemic circulation in vivo, these results validate the platform's robustness and passive tumor accumulation, highlighting its potential as a versatile vehicle for the delivery of diagnostic radionuclides.
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