Evidence map›Paper›PMID 42550406›Full record

ArticleJournal of neuro-oncology2026

The risk of sinus vein thrombosis in patients treated with intraoperative radiotherapy for sinus adjacent tumours.

Jason Bakos, Franz Stangl, Lars Behrens, Ansgar Berlis, Maria Neu, Georg Stüben, Björn Sommer, Nadine Lilla, Dorothee Mielke, Klaus Henning Kahl and 1 more

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jason BakosDepartment of Neurosurgery, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany. jason.bakos@uk-augsburg.de.ORCID http://orcid.org/0009-0006-2240-6337
Franz StanglDepartment of diagnostic and interventional Neuroradiology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Lars BehrensDepartment of diagnostic and interventional Neuroradiology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Ansgar BerlisDepartment of diagnostic and interventional Neuroradiology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Maria NeuDepartment of Radiooncology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Georg StübenDepartment of Radiooncology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Björn SommerDepartment of Neurosurgery, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Nadine LillaDepartment of Neurosurgery, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Dorothee MielkeDepartment of Neurosurgery, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Klaus Henning KahlDepartment of Radiooncology, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.
Philipp KraussDepartment of Neurosurgery, University Hospital Augsburg, Stenglingstrasse 2, 86156, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCerebral sinus vein thrombosis (SVT) is a feared complication of brain tumour surgery, especially in sinus adjacent locations. In the comprehensive treatment of brain metastases (BM) intraoperative radiotherapy (IORT) is recently being established as a safe alternative to postoperative adjuvant stereotactic radiosurgery (SRS). However, uncertainty of on the risk about SVT keeps surgeons reluctant to its use in sinus adjacent locations. Aim of this study is to investigate the risk of SVT in patients undergoing IORT compared to standard postoperative SRS.

methodsWe performed a retrospective analysis of 166 patients undergoing resection for histologically confirmed BM, of which 71 (42.8%) received IORT and 95 (57.2%) postoperative SRS. Tumour location, proximity to major dural venous sinuses, presence of SVT on postoperative imaging, timing of postoperative imaging, and, in SRS patients, time from surgery to radiotherapy were analyzed.

resultsPostoperative SVT occurred in 5 patients (3.0%). There was no significant difference in SVT rates in the IORT (n = 2, 2.8%) and SRS (n = 3, 3.2%) groups (p = 1.0). All SVT cases occurred in sinus-adjacent lesions and remained clinically asymptomatic. Time to postoperative imaging did not differ in the two treatment groups. Time to imaging and, for the SRS group, time to radiation therapy, did not differ between the thrombosis and non-thrombosis groups (Mann-Whitney U = 3289.5, Z = - 0.283, p = 0.777 and Mann-Whitney U = 100.0, p = 0.419 respectively).

conclusionIORT was not associated with increased risk for SVT compared to surgery with post-operative SRS.

Indexed as

Brain NeoplasmsPostoperative ComplicationsRadiosurgerySinus Thrombosis, IntracranialAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIntraoperative CareMaleMiddle AgedRetrospective StudiesBrain metastasisIntraoperative radiotherapyNeurooncologySinus vein thrombosis

Identifiers

PMID42550406

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