ArticleJournal of autism and developmental disorders2026
Burden of Co-occurring Conditions and Perinatal Predictors of Epilepsy in Autism Spectrum Disorder: A Cross-Sectional Study of 1015 Children From Northwestern Mexico.
Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChildren with ASD frequently present with multiple co-occurring conditions affecting clinical management and quality of life. Systematic data on the burden of co-occurring conditions and perinatal risk factors remain scarce in Latin America. This study aimed to characterize the co-occurring condition profile, burden, and perinatal predictors in a large ASD cohort from Northwestern Mexico, examining their relationships with ASD severity and intellectual functioning.
methodsThis retrospective, cross-sectional study reviewed 1015 children with ASD (January 2022-January 2024) at the Sinaloa Autism Center, Culiacán, Mexico. ASD was diagnosed per DSM-5 by a board-certified pediatric neurologist. Severity was assessed using the CARS-2; intellectual functioning was assessed using the WISC-IV in 508 patients (≥ 6 years). Co-occurring condition burden was scored across seven domains. Three binary logistic regression models were constructed for epilepsy, ADHD, and sleep disorders.
resultsOf 1,015 children, 83.3% were male (ratio 4.9:1). Median co-occurring condition burden was 3 per patient (IQR 2-4); 58.3% had ≥ 3 simultaneous co-occurring conditions. Language disorder was most prevalent (91.2%), followed by feeding/gastrointestinal disorders (69.8%), sleep disorders (63.2%), ADHD (33.8%), anxiety (12.9%), epilepsy (8.9%), and depression (3.0%). Perinatal asphyxia was the only independent predictor of epilepsy (adjusted OR = 2.02; 95% CI: 1.14-3.57; p = 0.016). ADHD was inversely associated with ASD severity (OR = 0.71; p = 0.015) and positively with higher intellectual functioning (p = 0.016).
conclusionThis largest ASD cohort from Northwestern Mexico reveals an extremely high multimorbidity burden. Perinatal asphyxia independently predicts epilepsy in ASD, representing a concrete, preventable target. Systematic multidisciplinary co-occurring condition screening at ASD diagnosis is strongly recommended across all levels of care in Mexico.
Indexed as
Identifiers
42550384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.